{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:58:32Z","timestamp":1790762312197,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T00:00:00Z","timestamp":1582588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Patients with primary Sj\u00f6gren's syndrome (pSS) have an increased risk of developing diffuse large B\u2010cell lymphoma (DLBCL), which is an aggressive and heterogeneous non\u2010Hodgkin lymphoma. This study aimed to characterize DLBCLs in patients with pSS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We identified 18 patients with DLBCL and pSS over a 22\u2010year period. Based on the 2016 WHO guidelines, we characterized DLBCL based on immunohistochemical tests using a broad panel of antibodies, and an Epstein\u2010Barr virus (EBV) test using in situ hybridization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median time from initial pSS symptom onset to the DLBCL diagnosis was 20.5\u00a0years and the median time from the pSS diagnosis until the DLBCL diagnosis was 14\u00a0years. After the lymphoma diagnosis, the median overall survival was 3\u00a0months (range: 0\u2010212\u00a0months) and the 5\u2010year overall survival rate was 37.5%. Thirteen DLBCLs were re\u2010classified as DLBCL, not otherwise specified (NOS) in nine cases; EBV\u2010positive DLBCL, NOS in two cases; and T\u2010cell\/histiocyte\u2010rich large B\u2010cell lymphoma in two cases. Five cases of DLBCLs were not re\u2010classified because their EBV status was unknown. The Hans algorithm, which uses a combination of staining for CD10, BCL6, and MUM1, was used to classify the DLBCLs into the germinal center B\u2010cell (GCB) subtype for three cases and the non\u2010GCB subtype for nine cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results indicate that DLBCL tends to occur late in pSS cases and is mainly related to the non\u2010GCB subtype of DLBCL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13800","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T03:15:00Z","timestamp":1582686900000},"page":"540-548","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Characteristics of diffuse large B\u2010cell lymphoma in patients with primary Sj\u00f6gren's syndrome"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8428-1281","authenticated-orcid":false,"given":"Vadim Romanovich","family":"Gorodetskiy","sequence":"first","affiliation":[{"name":"Department of Intensive Methods of Therapy V.A. Nasonova Research Institute of Rheumatology Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalya Alexandrovna","family":"Probatova","sequence":"additional","affiliation":[{"name":"Department of Pathology N.N. Blokhin Russian Cancer Research Center Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir Ivanovich","family":"Vasilyev","sequence":"additional","affiliation":[{"name":"Department of Intensive Methods of Therapy V.A. Nasonova Research Institute of Rheumatology Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24287"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-119974"},{"key":"e_1_2_9_4_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow S","year":"2017"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21591"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1545"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291402"},{"key":"e_1_2_9_8_1","first-page":"5","article-title":"Staging and response assessment in lymphomas: the new Lugano classification","volume":"4","author":"Cheson BD","year":"2015","journal-title":"Chin Clin Oncol"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(96)80019-9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10221"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-014-3051-x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.041186"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390508"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2011.04.006"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.2.766"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3181b76ab5"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000046539"},{"key":"e_1_2_9_18_1","first-page":"672","article-title":"Primary cutaneous large B\u2010cell lymphoma of the legs in a patient with primary Sjogren's syndrome","volume":"21","author":"Selva\u2010O'Callaghan A","year":"2003","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_9_19_1","first-page":"576","article-title":"Upper gastrointestinal bleeding in a patient with Sjogren syndrome","volume":"108","author":"Cortes M","year":"2016","journal-title":"Rev Esp Enferm Dig"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.49.89"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-006-0401-4"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22476"},{"key":"e_1_2_9_23_1","first-page":"2786","article-title":"Characteristics of patients with primary Sjogren's syndrome and non\u2010Hodgkin's lymphoma: analysis of 9 cases","volume":"89","author":"Jia N","year":"2009","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_9_24_1","first-page":"45","article-title":"Diffuse large B\u2010cell lymphoma as a sequela of Sj\u00f6gren's syndrome: a case report","volume":"1","author":"Horvath IF","year":"2009","journal-title":"Open Autoimmun J"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep404"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31824125e4"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-13-149"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120869"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.46.8439"},{"key":"e_1_2_9_30_1","first-page":"6669","article-title":"Cancer diagnosis in a cohort of patients with Sjogren's syndrome and rheumatoid arthritis: a single\u2010center experience and review of the literature","volume":"34","author":"Boussios S","year":"2014","journal-title":"Anticancer Res"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2016.03.005"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15100"},{"key":"e_1_2_9_33_1","unstructured":"L Vasaitis Acta Universitatis Uppsala 94"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.56.9.521"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2014.12.001"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22277"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/35000501"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012914"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1732008100"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/106689690601400108"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3112"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.119"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-345256"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.13800","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13800","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.13800","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T13:34:38Z","timestamp":1693834478000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.13800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,25]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/1756-185X.13800"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.13800","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,25]]},"assertion":[{"value":"2019-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}