{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:45:17Z","timestamp":1765295117793,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Cumhuriyet University Scientific Research Projects (C\u00dcBAP) Commission","award":["Project No: T-839"],"award-info":[{"award-number":["Project No: T-839"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Although the etiopathogenesis of fibromyalgia syndrome (FM) is not yet clear, central sensitization is thought to be responsible for the pathogenesis of FM. The aim of this study was to compare the serum cathepsin S (CatS) and cystatin C (CysC) levels between patients with FM and healthy control subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was conducted in the Physical Medicine and Rehabilitation Clinic between January 2019 and October 2019. The study included 145 FM patients newly diagnosed with primary FM according to the 2010 American College of Rheumatology criteria and 129 healthy volunteers. The age, gender, and body mass index (BMI) of the participants were recorded. Venous blood samples were collected from both groups for the measurement of the levels of serum CatS and CysC. The functional status of FM patients was evaluated using the Fibromyalgia Impact Questionnaire (FIQ).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No statistically significant difference was determined between the patient and control groups in terms of age, gender, and BMI (<jats:italic>P\u00a0<\/jats:italic>&gt;\u00a0.05). A comparison of the serum CatS and CysC levels of the FM and control groups revealed a statistically significant difference (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). No correlation was determined between FIQ and serum CatS and CysC levels (<jats:italic>P\u00a0<\/jats:italic>&gt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum CatS and CysC levels were found to be higher in FM patients. However, there was no correlation between the functional status of FM patients and serum CatS and CysC levels. These results can be of guidance for further clinical studies of the etiopathogenesis and treatment of FM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13840","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T01:14:11Z","timestamp":1587345251000},"page":"966-969","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["High levels of cathepsin S and cystatin C in patients with fibromyalgia syndrome"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5783-4389","authenticated-orcid":false,"given":"Ibrahim","family":"Kocak","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Faculty of Medicine Cumhuriyet University Sivas Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0418-0155","authenticated-orcid":false,"given":"Sami","family":"Hizmetli","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Division of Rheumatology Faculty of Medicine Cumhuriyet University Sivas Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7132-1325","authenticated-orcid":false,"given":"Ay\u00e7a","family":"Tas","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Diet Faculty of Health Sciences Cumhuriyet University Sivas Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5284-2256","authenticated-orcid":false,"given":"Ahmet","family":"Karadag","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Faculty of Medicine Cumhuriyet University Sivas Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1436-5145","authenticated-orcid":false,"given":"Cemile","family":"Zontul","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Medicine Cumhuriyet University Sivas Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0562-7457","authenticated-orcid":false,"given":"Yavuz","family":"Silig","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Medicine Cumhuriyet University Sivas Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,19]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.5606\/ArchRheumatol.2019.7265"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1515\/reveh-2015-0040"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.4081\/reumatismo.2014.767"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1093\/brain\/awh098"},{"doi-asserted-by":"publisher","key":"e_1_2_7_6_1","DOI":"10.1016\/j.mayocp.2015.03.014"},{"doi-asserted-by":"publisher","key":"e_1_2_7_7_1","DOI":"10.1038\/ncpneuro0113"},{"issue":"1","key":"e_1_2_7_8_1","first-page":"77","article-title":"Mechanisms of neuropathic pain","volume":"52","author":"Campbell JN","year":"2007","journal-title":"James"},{"doi-asserted-by":"publisher","key":"e_1_2_7_9_1","DOI":"10.1016\/j.expneurol.2011.09.012"},{"doi-asserted-by":"publisher","key":"e_1_2_7_10_1","DOI":"10.1016\/j.neuron.2009.09.033"},{"doi-asserted-by":"publisher","key":"e_1_2_7_11_1","DOI":"10.1002\/glia.21042"},{"doi-asserted-by":"publisher","key":"e_1_2_7_12_1","DOI":"10.2147\/JPR.S128508"},{"doi-asserted-by":"publisher","key":"e_1_2_7_13_1","DOI":"10.1515\/hsz-2015-0114"},{"doi-asserted-by":"publisher","key":"e_1_2_7_14_1","DOI":"10.1016\/S0167-4838(99)00263-0"},{"doi-asserted-by":"publisher","key":"e_1_2_7_15_1","DOI":"10.1002\/acr.20140"},{"key":"e_1_2_7_16_1","first-page":"728","article-title":"The fibromyalgia impact questionnaire: development and validation","volume":"18","author":"Burckhardt CS","year":"1991","journal-title":"J Rheumatol"},{"doi-asserted-by":"publisher","key":"e_1_2_7_17_1","DOI":"10.1007\/s002960000077"},{"doi-asserted-by":"publisher","key":"e_1_2_7_18_1","DOI":"10.1080\/03009740510026337"},{"doi-asserted-by":"publisher","key":"e_1_2_7_19_1","DOI":"10.3390\/cells8030264"},{"doi-asserted-by":"publisher","key":"e_1_2_7_20_1","DOI":"10.1007\/s12018-011-9095-5"},{"doi-asserted-by":"publisher","key":"e_1_2_7_21_1","DOI":"10.1093\/rheumatology\/keu486"},{"doi-asserted-by":"publisher","key":"e_1_2_7_22_1","DOI":"10.3109\/03009742.2014.882979"},{"doi-asserted-by":"publisher","key":"e_1_2_7_23_1","DOI":"10.1038\/ni.3793"},{"doi-asserted-by":"publisher","key":"e_1_2_7_24_1","DOI":"10.2741\/3089"},{"doi-asserted-by":"publisher","key":"e_1_2_7_25_1","DOI":"10.1097\/AJP.0b013e31829ca60b"},{"key":"e_1_2_7_26_1","first-page":"1","article-title":"Cystatin C in evaluating renal function in ureteral calculi hydronephrosis in adults","volume":"4","author":"Mao W","year":"2019","journal-title":"Kidney Blood Press Res"},{"key":"e_1_2_7_27_1","first-page":"8541402","article-title":"Association of cystatin C with metabolic syndrome and its prognostic performance in non\u2010ST\u2010segment elevation acute coronary syndrome with preserved renal function","author":"Mao Q","year":"2019","journal-title":"Biomed Res Int"},{"doi-asserted-by":"publisher","key":"e_1_2_7_28_1","DOI":"10.1016\/j.arr.2016.06.003"},{"doi-asserted-by":"publisher","key":"e_1_2_7_29_1","DOI":"10.1016\/S0304-3959(02)00403-7"},{"doi-asserted-by":"publisher","key":"e_1_2_7_30_1","DOI":"10.1016\/S0306-4522(00)00573-X"},{"key":"e_1_2_7_31_1","first-page":"35","article-title":"Can we use cystatin C as a pain marker?","volume":"3","author":"Akba\u015f MS","year":"2006","journal-title":"Turk J Obstet Gynecol"},{"doi-asserted-by":"publisher","key":"e_1_2_7_32_1","DOI":"10.1007\/s10072-012-1022-0"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.13840","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13840","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.13840","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13840","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T10:06:59Z","timestamp":1693822019000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.13840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,19]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1111\/1756-185X.13840"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.13840","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"type":"print","value":"1756-1841"},{"type":"electronic","value":"1756-185X"}],"subject":[],"published":{"date-parts":[[2020,4,19]]},"assertion":[{"value":"2020-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}