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In recent years, a number of susceptibility non\u2010human leukocyte antigen (HLA) genes of PsA have been revealed, which also act as important factors in the pathogenesis of PsA as well as HLA genes. By searching the databases National Center for Biotechnology Information, Google and PubMed, 37 articles are included and 50 susceptibility non\u2010HLA genes for PsA are presented, such as <jats:italic>IL23A<\/jats:italic>, <jats:italic>TNIP1<\/jats:italic>, <jats:italic>TYK2<\/jats:italic>, <jats:italic>STAT4<\/jats:italic>, <jats:italic>IL12B<\/jats:italic>, <jats:italic>RUNX3<\/jats:italic> and <jats:italic>TRAF3IP2<\/jats:italic>. In these non\u2010HLA genes, some are common genes shared with other diseases, whereas most of these susceptibility genes are related to the pathogenesis of PsA by activation or inhibition of the signaling pathways. Several signaling pathways possibly implicated in the pathogenesis of PsA are introduced in this paper, including the 2 mainly signaling pathways, IL23\/Th17 signaling pathway and NF\u2010\u03baB signaling pathway, and the other involved signaling pathways, such as JAK\u2010STAT signaling pathway and MAPK signaling pathway.<\/jats:p>","DOI":"10.1111\/1756-185x.13879","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T21:11:28Z","timestamp":1596748288000},"page":"1288-1296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Psoriatic arthritis: A systematic review of non\u2010HLA genetic studies and important signaling pathways"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3809-4036","authenticated-orcid":false,"given":"Jingjing","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology Anhui Provincial Corps Hospital 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