{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:26Z","timestamp":1787013746572,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Fatigue is an important yet infrequently evaluated component in patients with rheumatoid arthritis (RA) and may have a major impact on quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate fatigue, identify factors associated with fatigue and assess the effect of fatigue on health\u2010related quality of life (HRQoL) in a multi\u2010ethnic cohort of RA patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study was performed in patients who fulfilled European League Against Rheumatism\/ American College of Rheumatology 2010 criteria for RA. Functional Assessment of Chronic Illness Therapy \u2010 Fatigue (FACIT\u2010F) questionnaire was used to assess fatigue. Potential factors for fatigue were categorized into RA\u2010related (gender, seropositivity [rheumatoid factor and\/or anti\u2010citrullinated protein antibody], disease duration, visual analog scale pain score, Disease Activity Score of 28 joints \u2013 erythrocyte sedimentation rate [DAS28\u2010ESR], ESR, hemoglobin level, functional disability [Health Assessment Questionnaire \u2010 Disability Index, HAQ\u2010DI score], EQ\u20105D\u20103L, concomitant prednisolone use and number of conventional synthetic disease\u2010modifying anti\u2010rheumatic drugs [csDMARDs] used) and non\u2010RA\u2010related (age, body mass index, ethnicity and number of co\u2010morbidities).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 214 patients (86.9% female) were included; the median age was 62 (25\u201091) years and 67.3% were seropositive. Seventy\u2010six (33.5%) patients had moderate disease activity, 12 (5.6%) had high disease activity and 152 (71%) patients had mild difficulties to moderate disability HAQ\u2010DI scores. Median of total FACIT\u2010F score was 113.2 (36.3\u2010160.0). Joint factors of younger age, longer disease duration, higher HAQ score (increased functional disability), and lower EQ\u20105D (poorer HRQoL) were significantly associated with higher levels of fatigue (all\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Fatigue was associated with functional disability and has a significant impact on HRQoL in RA. Fatigue assessment should be considered in routine clinical practice for RA patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.13897","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T07:39:28Z","timestamp":1593416368000},"page":"1088-1093","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Fatigue and associated factors in a multi\u2010ethnic cohort of rheumatoid arthritis patients"],"prefix":"10.1111","volume":"23","author":[{"given":"Hwai Jien","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Rheumatology Department of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3416-1369","authenticated-orcid":false,"given":"Lydia Say Lee","family":"Pok","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choung Min","family":"Ng","sequence":"additional","affiliation":[{"name":"Institute of Mathematical Sciences Faculty of Science University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8139-7764","authenticated-orcid":false,"given":"Fariz","family":"Yahya","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sargunan","family":"Sockalingam","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying Chew","family":"Tee","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3347-1362","authenticated-orcid":false,"given":"Jasmin","family":"Raja","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar578"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker014"},{"issue":"8","key":"e_1_2_7_4_1","first-page":"1407","article-title":"The prevalence and meaning of fatigue in rheumatic disease","volume":"23","author":"Wolfe F","year":"1996","journal-title":"J Rheumatol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel021"},{"issue":"4","key":"e_1_2_7_6_1","first-page":"639","article-title":"Comparison of self\u2010reported fatigue in rheumatoid arthritis and controls","volume":"22","author":"Belza BL","year":"1995","journal-title":"J Rheumatol"},{"issue":"1","key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"e000041","DOI":"10.1136\/rmdopen-2014-000041","article-title":"Fatigue in rheumatoid arthritis; 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