{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:15:53Z","timestamp":1787598953621,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the National Key Research and Development Program of China","award":["2016YFC0901500"],"award-info":[{"award-number":["2016YFC0901500"]}]},{"name":"the Capital Medical Research and Development Fund","award":["2016-4-40112"],"award-info":[{"award-number":["2016-4-40112"]}]},{"name":"the CAMS Innovation Fund for Medical Sciences","award":["2017-I2M-3-001"],"award-info":[{"award-number":["2017-I2M-3-001"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To explore the relevance of disease duration with axial skeletal lesions in synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome based on computed tomography (CT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who had undergone whole\u2010spine CT were included from a previously reported single\u2010center cohort of SAPHO syndrome. Patients with previous treatments of bisphosphates, biological agents or surgeries were excluded. Sites of axial skeletal involvement were reviewed including the spine, sacroiliac joints, and anterior chest wall. Duration of osteoarticular involvement was defined as the interval between the onset of osteoarticular symptoms and the CT evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010one patients (54 female and 27 male) were included in the study. The mean disease duration was 26.9\u00a0\u00b1\u00a034.9\u00a0months. Fifty (63.0%) patients showed spinal lesions on CT. The average numbers of involved vertebral segments for corner and endplate lesions were 3.16\u00a0\u00b1\u00a03.51 and 0.73\u00a0\u00b1\u00a01.85 respectively. Sixty\u2010eight (84.0%) patients exhibited abnormalities in the anterior chest wall. The number of involved vertebral segments showed poor correlation with disease duration for both corner lesions (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.051,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.043) and endplate lesions (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.137,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.001). Patients with costoclavicular involvement showed remarkably longer disease duration than those without (49.3\u00a0\u00b1\u00a047.7\u00a0months vs 18.0\u00a0\u00b1\u00a023.5\u00a0months,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.006), while no significant difference was detected regarding other structures in the anterior chest wall.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Costoclavicular involvement is a hallmark of long disease duration in SAPHO syndrome. Corner and endplate lesions in the vertebrae and sacroiliac involvement may not relate to disease course.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.13899","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T03:45:33Z","timestamp":1593229533000},"page":"1152-1158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Axial skeletal lesions and disease duration in SAPHO syndrome: A retrospective review of computed tomography findings in 81 patients"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8527-1680","authenticated-orcid":false,"given":"Chen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine Peking Union Medical College Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqian","family":"Ye","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking Union Medical College Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7808-9867","authenticated-orcid":false,"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Peking Union Medical College Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenrui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking Union Medical College Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Peking Union Medical College Hospital Beijing China"},{"name":"Beijing Key Laboratory for Genetic Research of Skeletal Deformity Beijing China"},{"name":"Medical Research Center of Orthopedics Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Peking Union Medical College Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking Union Medical College Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2012.05.006"},{"key":"e_1_2_10_3_1","first-page":"187","article-title":"Acne\u2010pustulosis\u2010hyperostosis\u2010osteitis syndrome. 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