{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T10:08:36Z","timestamp":1778580516284,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T00:00:00Z","timestamp":1597190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Faculty of Medicine, Grant office, Assiut University","award":["2018\/07\/17-002"],"award-info":[{"award-number":["2018\/07\/17-002"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Disturbances in autophagy are known to be implicated in autoimmune disorders. Many studies have connected polymorphisms in autophagy\u2010related gene 5 (ATG\u20105) to systemic lupus erythematosus (SLE). Our aim was the determination of the expression level of ATG\u20105, Beclin\u20101 and microtubule\u2010associated protein\u2010light chain 3 (LC\u20103) in Egyptian SLE patients to investigate the impact of disturbances in autophagy genes on the incidence and progression of the disease. Also, we investigated the incidence of single nucleotide polymorphism (SNP) rs573775 in ATG\u20105 gene among Egyptian SLE patients. Our results showed that the mean levels of Beclin\u20101, LC\u20103 and interleukin (IL)\u201010 transcripts were significantly higher in SLE patients compared to healthy controls. The previous transcripts were positively correlated with SLE Disease Activity Index (SLEDAI). Beclin\u20101 and LC\u20103 transcripts were negatively correlated to complement component 3 (C3) levels. Only LC\u20103 transcripts were negatively correlated to complement component 4 (C4). The rs573775 SNP of ATG\u20105 with the variant allele was significantly associated with disease susceptibility, conferring a higher risk of SLE development. This variant allele was more prevalent in patients below 30\u00a0years, patients with anemia and in patients with anti\u2010double\u2010stranded DNA (dsDNA), confirming the essential role of ATG\u20105 polymorphism in the susceptibility of Egyptian patients to SLE.<\/jats:p>","DOI":"10.1111\/1756-185x.13910","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T07:31:12Z","timestamp":1597217472000},"page":"1226-1232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Evaluation of autophagy\u2010related genes in Egyptian systemic lupus erythematosus patients"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3949-2121","authenticated-orcid":false,"given":"Ayat M.","family":"Kamel","sequence":"first","affiliation":[{"name":"Microbiology and Immunology Department Faculty of Pharmacy Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed S.","family":"Badary","sequence":"additional","affiliation":[{"name":"Microbiology and Immunology Department Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wegdan A.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Microbiology and Immunology Department Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghada H.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Rheumatoloy Unit Internal Medicine Department Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A.","family":"El\u2010Feky","sequence":"additional","affiliation":[{"name":"Microbiology and Immunology Department Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12768"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-194175"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5371"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01512"},{"issue":"1","key":"e_1_2_9_6_1","first-page":"1","article-title":"Expression of autophagy related genes mTOR, Becline\u20101, LC3 and p62 in the peripheral blood mononuclear cells of systemic lupus erythematosus","volume":"6","author":"Wu Z\u2010Z","year":"2017","journal-title":"Am J Clin Exp Immunol"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/08830185.2013.879711"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.81"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078756"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2016.49.8.081"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2014-202356"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2014.81"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2524"},{"issue":"3","key":"e_1_2_9_14_1","first-page":"403","article-title":"Recent insights into the role of autophagy in the pathogenesis of rheumatoid arthritis","volume":"55","author":"Dai Y","year":"2015","journal-title":"Rheumatology"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000442921"},{"issue":"9","key":"e_1_2_9_16_1","first-page":"1725","article-title":"Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. 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