{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T06:59:11Z","timestamp":1776754751646,"version":"3.51.2"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T00:00:00Z","timestamp":1595980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"AbbVie Ltd","award":["P15-238"],"award-info":[{"award-number":["P15-238"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Peripheral features contribute to disease burden in ankylosing spondylitis (AS). This study investigated the frequency of peripheral disease and effectiveness of adalimumab among Korean patients with AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Peripheral disease was evaluated in consecutively enrolled patients with active AS (Bath Ankylosing Spondylitis Disease Activity Index [BASDAI] score\u00a0\u2265\u00a04). An adult subpopulation was subsequently enrolled in a prospective, observational study and received adalimumab 40\u00a0mg, every 2\u00a0weeks. During a 52\u2010week follow\u2010up, AS disease activity was assessed by BASDAI score, and effectiveness in peripheral disease assessed via changes in Maastricht Ankylosing Spondylitis Enthesitis Score (MASES; 0\u201013), swollen joint and tender joint counts (SJC, 0\u201044; TJC, 0\u201046), and dactylitic digits from baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1161 Korean patients with AS, 178 (15.3%) and 306 (26.4%) had enthesitis and peripheral arthritis, respectively; dactylitis was diagnosed in 28 patients (2.4%). Of 201 patients enrolled in the observational study, 46.3%, 33.3%, and 3.0% had enthesitis, peripheral arthritis, and dactylitis, respectively. Overall, 75.1% of patients achieved &gt;50% improvement in BASDAI score by week 12. Mean MASES was significantly reduced from 2.67 at baseline to 0.85 and 0.34 at weeks 12 and 52, respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). Similarly, SJC and TJC improved significantly from 2.58 and 3.49 at baseline to 0.80 and 1.68, respectively, by week 12 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). Dactylitis was resolved in all affected patients by week 28.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Of these Korean patients with AS, those who received adalimumab demonstrated higher prevalence for peripheral symptoms and, subsequently, adalimumab treatment improved peripheral features of their AS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13917","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T07:05:19Z","timestamp":1596006319000},"page":"1175-1183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Frequency of peripheral diseases in Korean patients with ankylosing spondylitis and the effectiveness of adalimumab"],"prefix":"10.1111","volume":"23","author":[{"given":"Sang\u2010Hoon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Rheumatology Hospital at Gang dong College of Medicine Kyung Hee University Seoul 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