{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:08:55Z","timestamp":1791558535357,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T00:00:00Z","timestamp":1596326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fundamental Research Grant Scheme, Malaysia Ministry of Education","award":["FP017-2017A"],"award-info":[{"award-number":["FP017-2017A"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Rheumatoid arthritis (RA) is associated with chronic periodontitis (CP) due to shared risk factors, immuno\u2010genetics and tissue destruction pathways. Human cathelicidin LL\u201037 has been suggested as a possible mechanistic link for these diseases. This study investigated the levels of salivary and serum LL\u201037 in subjects with RA and CP and their correlation with disease parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Subjects were allocated into RA (n\u00a0=\u00a049) or non\u2010RA (NRA) (n\u00a0=\u00a055) groups, where 3 subgroups were further established; chronic periodontitis (CP), gingivitis (G) and periodontal health (H). Demographic and periodontal parameters were collected. Rheumatology data were obtained from hospital records. Serum and salivary LL\u201037 levels were measured using enzyme\u2010linked immunosorbent assay and compared for all groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For salivary LL\u201037, RA\u2010CP was significantly higher than NRA\u2010G and NRA\u2010H (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.047). For serum LL\u201037, all RA and NRA\u2010CP were significantly higher than NRA\u2010G and NRA\u2010H (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.024). Salivary LL\u201037 correlated negatively with clinical attachment loss (CAL) (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.048), but positively with erythrocyte sedimentation rate (ESR) in RA\u2010H (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.045). Serum LL\u201037 showed positive correlation with ESR (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.037) in RA\u2010G, with C\u2010reactive protein (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.017) in RA\u2010H, but negative correlation with number of teeth (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002) in NRA\u2010CP. Rheumatology data correlated positively with periodontal parameters in RA\u2010CP group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NRA\u2010CP subjects with high serum LL\u201037 should receive comprehensive periodontal therapy. Positive correlation between rheumatology data and periodontal parameters showed that RA disease stability may be obtained by assessing the periodontal condition. Periodontal therapy is necessary to compliment RA treatment to achieve optimum outcome for RA patients with concurrent CP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13919","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T03:25:20Z","timestamp":1596425120000},"page":"1344-1352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Salivary and serum cathelicidin LL\u201037 levels in subjects with rheumatoid arthritis and chronic periodontitis"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5795-4249","authenticated-orcid":false,"given":"Chia Wei","family":"Cheah","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry Faculty of Dentistry University of Malaya Kuala Lumpur 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