{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T09:53:42Z","timestamp":1770458022864,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T00:00:00Z","timestamp":1597622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate anti\u2010cyclic citrullinated peptide (anti\u2010CCP) and rheumatoid factor (RF) in relation to ultrasound\u2010detected joint inflammation and bone erosion in patients with rheumatoid arthritis (RA) as previous studies have mainly utilized radiographic damage as imaging outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In this cross\u2010sectional study, patients were grouped based on their Disease Activity Score at 28 joints (DAS28\u00a0&lt;\u00a03.2, DAS28\u00a0\u2265\u00a03.2). Ultrasound variables (power Doppler and gray scale joint inflammation graded 0\u20103 semi\u2010quantitatively; bone erosion graded Yes\u00a0=\u00a01\/No\u00a0=\u00a00 dichotomously) were correlated with antibodies levels using Pearson correlation. Simple linear regression was used to characterize relationships between variables. Receiver operating characteristic (ROC) analysis was performed to determine statistically optimal cut\u2010off values for identifying patient subgroups with ultrasound erosion scores &gt;25th, &gt;50th and &gt;75th percentiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One thousand and eighty joints and 1800 joint recesses from 36 peripheral joint sites were scanned in 30 adult RA patients (mean disease duration, 70.3\u00a0months; 93.3% female; 93.3% anti\u2010CCP positive; 93.3% RF positive). In the DAS28\u00a0&lt;\u00a03.2 group, no significant correlations were found between antibody levels and ultrasound variables. In the DAS28\u00a0\u2265\u00a03.2 group, anti\u2010CCP levels correlated significantly (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.46, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.048) and were predictive (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.048) of ultrasound erosion scores. Area under the ROC curve based on cut\u2010off anti\u2010CCP level of \u226595.2 to identify patients with ultrasound erosion scores &gt;7 (75th percentile) was 0.72 (sensitivity\u00a0=\u00a083.3%, specificity\u00a0=\u00a053.8%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The association of anti\u2010CCP and RF with joint damage appears to differ in RA. Among patients with at least moderate disease activity (DAS28\u00a0\u2265\u00a03.2), anti\u2010CCP\u2014but not RF\u2014is associated with joint damage, being moderately correlated with ultrasound\u2010detected bone erosion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13933","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T02:30:02Z","timestamp":1598581802000},"page":"1337-1343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Anti\u2010cyclic citrullinated peptide but not rheumatoid factor is associated with ultrasound\u2010detected bone erosion among rheumatoid arthritis patients with at least moderate disease activity"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6944-8220","authenticated-orcid":false,"given":"York Kiat","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Singapore 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