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Functionally, IL\u201035 can promote the proliferation and activation of regulatory T cells (Tregs) and suppress the function of T helper 17 (Th17) cells and other inflammatory cells to inhibit immune responses. In recent years, an abnormal IL\u201035 expression causing a Th17\/Treg imbalance has been associated with the development and progression of several connective tissue diseases (CTDs), such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), dermatomyositis (DM)\/polymyositis (PM), and primary Sj\u00f6gren\u2019s syndrome (pSS). Here, we review the role of IL\u201035 in regulating the balance of Th17\/Treg responses in different types of CTDs and provide new insights into the role of IL\u201035 in these diseases.<\/jats:p>","DOI":"10.1111\/1756-185x.13962","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T20:46:53Z","timestamp":1601326013000},"page":"21-27","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Interleukin\u201035 regulates the balance of Th17 and Treg responses during the pathogenesis of connective tissue diseases"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5342-4152","authenticated-orcid":false,"given":"Di","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology The First Affiliated Hospital of Guangxi Medical University Nanning 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