{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:26:48Z","timestamp":1791228408257,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Cardiovascular (CV) risk and mortality associated with spondyloarthritis (SpA) remain controversial. Herein, we performed a meta\u2010analysis of the latest large\u2010scale population\u2010based studies to demonstrate the elevated risk of CV disease and mortality in patients with SpA than in the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MEDLINE and EMBASE databases were searched systematically for population\u2010based studies published between January 1997 and September 2019. Additional manual literature searches were also performed. All searches and data collection were performed independently by 2 reviewers. We calculated the risks of myocardial infarction (MI), stroke, and all\u2010cause mortality in a meta\u2010analysis and determined the risk ratios (RR) using the Mantel\u2013Haenszel method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 641 identified articles, 16 articles involving 18 cases met the inclusion criteria for our meta\u2010analysis; these included 12 cases of ankylosing spondylitis, five cases of psoriatic arthritis, and 1 case of undifferentiated SpA. Our meta\u2010analysis revealed a significantly high risk of MI (RR: 1.52; 95% CI: 1.29\u20101.80) and stroke (RR: 1.21; 95% CI: 1.0\u20101.47) in patients with SpA than in the general population. However, this increased risk was not significant in terms of all\u2010cause mortality (RR: 1.23; 95% CI: 0.96\u20101.57).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our meta\u2010analysis demonstrated that patients with SpA have a significantly increased risks of MI and stroke, but without a significant increase in the all\u2010cause mortality, than that in the general population. The higher risk of CV in patients with SpA than that in the general population indicates the need for strict risk factor correction and disease management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13970","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T11:04:47Z","timestamp":1600945487000},"page":"477-486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Cardiovascular morbidity and mortality in patients with spondyloarthritis: A meta\u2010analysis"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0765-347X","authenticated-orcid":false,"given":"Ji Hyoun","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Chungbuk National University Hospital  Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4662-4065","authenticated-orcid":false,"given":"In Ah","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Chungbuk National University Hospital  Cheongju Korea"},{"name":"Department of Internal Medicine, College of Medicine Chungbuk National University  Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-012-0274-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-10-14"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2015.05.006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2016.10.006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2018.17421"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_8_8_1","unstructured":"WellsGA SheaB O'ConnellD et al.The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta\u2010analyses. 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