{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:14:43Z","timestamp":1790673283578,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Scleroderma (SSc) is a chronic inflammatory autoimmune disease characterized by fibrosis in the skin and internal organs. In SSc, the heart, lung, kidney, gastrointestinal (GIS) system, muscle, and peri\u2010articular structures are damaged. There is no study of the relationship between SSc type, stage, pathogenesis, organ involvement, and Wnt signaling. In this study, we aimed to show the relationship of the Wnt gene family and antagonists in SSc subtypes and different organ involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010five SSc patients and 77 controls were included in this study. The gene expressions and protein levels of the Wnt family and antagonists were analyzed from blood samples. The relationship between these parameters and disease stage, type, and organ involvement were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Wnt\u20101, Wnt\u201010b, Wnt\u20102, and Wnt\u20106 gene expressions are increased and Axin\u20102, DKK\u20101, and Kremen protein expressions are decreased in SSc. Wnt\u20103a and Wnt\u201010a gene expressions are increased in generalized SSc compared to limited SSc. Wnt\u20101, Wnt\u20102 gene expressions are increased significantly in pulmonary arterial hypertension (PAH)(+) SSc compared to PAH(\u2212) SSc. There was a positive correlation between the modified Rodnan skin score and Wnt\u20102 in SSc. There was a significant positive correlation between GIS involvement score and Wnt\u20101, Wnt\u20102, Wnt\u20104, Wnt\u20108a, Wnt\u20109b in SSc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Wnt\u20101 and Wnt\u20102 were found higher in scleroderma and organ involvement. They may play a role in the pathogenesis of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13973","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T08:12:12Z","timestamp":1601453532000},"page":"1558-1567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Relationship of Wnt pathway activity and organ involvement in scleroderma types"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1510-2937","authenticated-orcid":false,"given":"Ay\u015fe","family":"Ko\u00e7ak","sequence":"first","affiliation":[{"name":"Kutahya Health Sciences University Kutahya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu","family":"Harmanc\u0131","sequence":"additional","affiliation":[{"name":"Dokuz Eylul University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcl","family":"G\u00fcner 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