{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:31:09Z","timestamp":1747182669713,"version":"3.40.5"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Antibodies against carbamylated proteins\/peptide (CarP) have been associated with severity in rheumatoid arthritis (RA) patients. However, their role in risk groups, specific targets and relation with periodontal disease (PD) is uncertain yet. The aim of this study was evaluated the association between the levels of anti\u2010CarP with clinical manifestation, human leukocyte antigen (HLA) alleles, periodontal activity markers, PD diagnosis, PD severity, and presence of <jats:italic>Porphyromonas gingivalis (P\u00a0gingivalis)<\/jats:italic> in relatives of patients with RA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and twenty\u2010four individuals with a family history of RA in first\u2010degree relatives (FDR) and 124 healthy individuals gender\u2010 and age\u2010matched, RA activity was assessed. Antibodies against carbamylated protein anti\u2010FCS\u2010Carp and 2 carbamylated peptides of fibrinogen were selected (anti\u2010Ca\u2010Fib2, anti\u2010Ca\u2010Fib3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Anti\u2010FCS\u2010Carp\u2010positive, anti\u2010Ca\u2010Fib2 and anti\u2010Ca\u2010Fib3 were more frequent in FDR than controls (25.0% vs 14.5%, 34.7% vs 15.3% and 33.1% vs 11.3%, respectively). Anti\u2010FCS\u2010CarP were associated with the HLA\u2010DRB1\u2010SE* 1402 allele (<jats:italic>P<\/jats:italic> = .035) and highly sensitive C\u2010reactive protein levels (<jats:italic>P<\/jats:italic> = .016), the anti\u2010Ca\u2010Fib2 antibodies were associated with the HLA\u2010DRB1\u2010SE* 1501 allele (<jats:italic>P<\/jats:italic> = .03), with non\u2010SE* 0901 allele (<jats:italic>P<\/jats:italic> = .01), the anti\u2010Ca\u2010Fib3 was associated with positive rheumatoid factor (<jats:italic>P<\/jats:italic> = .0012). The FDR condition was associated with the presence of anti\u2010Ca\u2010Fib3 (odds ratio [OR] =4.7; 95% CI\u00a0=\u00a01.8\u201011.7; <jats:italic>P<\/jats:italic> = .001) and painful joints (OR\u00a0=\u00a02.2; 95% CI\u00a0=\u00a01.01\u20104.68; <jats:italic>P<\/jats:italic> = .045); we also detected an important trend toward the presence of <jats:italic>P gingivalis<\/jats:italic> (OR\u00a0=\u00a01.9; 95% CI\u00a0=\u00a00.9\u20103.7; <jats:italic>P<\/jats:italic> = .062).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of anti\u2010FCS\u2010Carp, anti\u2010Ca\u2010Fib3 and anti\u2010Ca\u2010Fib2 antibodies may have a role for these antibodies as early biomarkers in the development of RA, probably including additional mechanisms related with other non\u2010SE alleles; the anti\u2010peptide antibodies proposed in the present study may represent a simpler way to identify antibodies directed to a specific target.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13977","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T17:58:58Z","timestamp":1604512738000},"page":"1698-1706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Anti\u2010carbamylated protein and peptide antibodies as potential inflammatory joint biomarkers in the relatives of rheumatoid arthritis patients"],"prefix":"10.1111","volume":"23","author":[{"given":"Lorena","family":"Chila\u2010Moreno","sequence":"first","affiliation":[{"name":"School of Dentistry, Cellular and Molecular Immunology Group\/INMUBO Universidad El Bosque Bogot\u00e1 Colombia"},{"name":"School of Medicine Clinical Immunology Group Universidad Militar Nueva Granada Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luz\u2010Stella","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Facultad de 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