{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T23:15:08Z","timestamp":1793488508857,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to identify predictive factors of glucocorticoid (GC)\u2010free remission in patients with polymyalgia rheumatica (PMR) treated with prednisolone (PSL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Among 75 PMR patients in our single\u2010center registry, this retrospective study targeted 20 patients who achieved GC\u2010free remission (Remission group) and 30 patients who continued treatment with PSL (PSL group) at 30\u00a0months from the initiation of PSL treatment (baseline).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference between Remission and PSL groups in baseline demographics. C\u2010reactive protein (CRP) decreased more rapidly at 1 and 3\u00a0months from baseline in the Remission group than in the PSL group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.013 and .046, respectively). Multivariate logistic regression analysis revealed that the normalization of CRP at 1\u00a0month was associated with the achievement of GC\u2010free remission (odds ratio\u00a0=\u00a05.83, 95% CI\u00a0=\u00a01.28\u201026.51, <jats:italic>P<\/jats:italic> = .023). In addition, when CRP at 1\u00a0month was\u00a0\u2264\u00a00.17\u00a0mg\/dL, as determined by receiver operating characteristic curve analysis, both the daily PSL dose and cumulative PSL dose were lower, and the rate of GC\u2010free remission higher, at 30\u00a0months compared to when CRP at 1\u00a0month was\u00a0&gt;\u00a00.17\u00a0mg\/dL (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.010, .049 and .004, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The normalization of CRP within 1\u00a0month from baseline predicted GC\u2010free remission in PMR patients treated with PSL, and resulted in a lower cumulative PSL dose.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13978","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T08:44:03Z","timestamp":1601455443000},"page":"1581-1586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Predictors 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