{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T23:08:21Z","timestamp":1771456101499,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The cross\u2010sectional study aimed to assess myocardial functions using global longitudinal strain (GLS) echocardiography and arrhythmia parameters with treatment naive newly diagnosed rheumatoid arthritis (RA) and no clinical evidence of cardiovascular disease (CVD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy seven newly diagnosed treatment\u2010naive RA patients were enrolled. Disease severity was evaluated according to rheumatoid factor (RF) and anti\u2010citrullinated protein antibodies (ACPA) positivity, and Disease Activity Score 28 C\u2010reactive protein (DAS28 CRP). Myocardial functions were assessed using conventional echocardiography and GLS technique and electrocardiogram parameters cQT and Tp\u2010e\/cQT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty three patients had severe disease while 54 patients were non\u2010severe. The Left Ventricle GLS (17.98\u00a0\u00b1\u00a01.24 vs 21.29\u00a0\u00b1\u00a01.03, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), cQT (428.71\u00a0\u00b1\u00a09.05 vs 394.61\u00a0\u00b1\u00a017.83, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), Tp\u2010e\/cQT (0.19\u00a0\u00b1\u00a00.02 vs 0.16\u00a0\u00b1\u00a00.01, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) for severe RA patients was reduced compared to RA non\u2010severe patients. Penalized maximum likelihood estimation logistic regression analysis revealed LVGLS as the only significantly independent predictor of severe RA disease (OR 0.70, CI 95% 0.52\u20100.92, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). Receiver operating characteristic (ROC) curves of the LVGLS was revealed 19.9 as GLS discriminative value with 88.8% positive predictive value for predicting severity. Severe RA risk increases when log\u2010odds value was over 0, corresponds to LVGLS value less than 18 by partial effect plots.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RA severity was associated with lower LV systolic myocardial function and increased arrhythmia parameters. Only LVGLS was significantly independent predictor of RA disease severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13992","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T16:41:21Z","timestamp":1602088881000},"page":"494-501","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Disease severity affects myocardial functions in patients with treatment\u2010naive early rheumatoid arthritis"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6767-6935","authenticated-orcid":false,"given":"Ender \u00d6zg\u00fcn","family":"\u00c7akmak","sequence":"first","affiliation":[{"name":"Department of Cardiology University of Medical Sciences Kartal Kosuyolu High Specialty Training and Research Hospital  \u0130stanbul 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