{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:56:08Z","timestamp":1781657768602,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate cognitive function in adult patients with juvenile idiopathic arthritis (JIA) and associated factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>We performed a cross\u2010sectional observational study of adult patients with JIA and a healthy control group (no inflammatory diseases) matched for age, gender, and educational level. Cognitive function was assessed using Wechsler Adult Intelligence Scale\u2010III. The cognitive domains measured were attention\/concentration, verbal function, visuospatial organization, working memory, and problem solving (Similarities). Other measures included clinical\u2010epidemiological characteristics, comorbid conditions, and treatment. We performed a descriptive bivariate analysis and logistic regression to identify factors associated with visuospatial involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population comprised 104 subjects (52 with JIA and 52 healthy controls). Patients with JIA had poorer results for visuospatial function, with a lower median scaled score on the Block Design test (5.0 [4.0\u20108.0] vs 8.0 [5.0\u201010.0]; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.014). The number of patients with scaled scores below the average range (&lt;8) in visuospatial organization was significantly greater in the JIA group (67.3% vs 40.4%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006). The multivariate analysis revealed time since diagnosis (odds ratio [95% CI], 1.03 [1.01\u20101.06]), inflammatory activity according to Juvenile Arthritis\u00a0Disease Activity Score 27\u2010joint count (1.94 [1.01\u20103.75]), and educational level (0.28 [0.08\u20100.94]) to be factors associated with visuospatial function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cognitive function in adult patients with JIA is poorer than in healthy controls at the expense of visuospatial function. Visuospatial function in JIA patients was inversely associated with disease duration, inflammatory activity, and lower educational level.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14009","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T15:51:42Z","timestamp":1603900302000},"page":"81-89","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of cognitive function in adult patients with juvenile idiopathic arthritis"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6173-2051","authenticated-orcid":false,"given":"Natalia","family":"Mena\u2010V\u00e1zquez","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA) M\u00e1laga Spain"},{"name":"UGC de Reumatolog\u00eda Hospital Regional Universitario de M\u00e1laga M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6421-5348","authenticated-orcid":false,"given":"Pablo","family":"Cabezudo\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA) M\u00e1laga Spain"},{"name":"Servicio de Neurolog\u00eda UGC de Neurociencias Hospital Regional Universitario de M\u00e1laga M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Ortiz\u2010M\u00e1rquez","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Universidad de M\u00e1laga M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0880-5319","authenticated-orcid":false,"given":"Gisela","family":"D\u00edaz\u2010Cordov\u00e9s Rego","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA) M\u00e1laga Spain"},{"name":"UGC de Reumatolog\u00eda Hospital Regional Universitario de M\u00e1laga M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Mu\u00f1oz\u2010Becerra","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA) M\u00e1laga Spain"},{"name":"Servicio de Neurolog\u00eda UGC de Neurociencias Hospital Regional Universitario de M\u00e1laga M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2284-7846","authenticated-orcid":false,"given":"Sara","family":"Manrique\u2010Arija","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA) M\u00e1laga Spain"},{"name":"UGC de Reumatolog\u00eda Hospital Regional Universitario de M\u00e1laga M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2962-9844","authenticated-orcid":false,"given":"Antonio","family":"Fern\u00e1ndez\u2010Nebro","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA) M\u00e1laga Spain"},{"name":"UGC de Reumatolog\u00eda Hospital Regional Universitario de M\u00e1laga M\u00e1laga Spain"},{"name":"Departamento de Medicina Universidad de M\u00e1laga M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60244-4"},{"key":"e_1_2_10_3_1","volume-title":"Juvenile Idiopathic Arthritis (JIA). 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