{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:23:04Z","timestamp":1761110584212,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T00:00:00Z","timestamp":1604707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To study joint damage severity in rheumatoid arthritis (RA) patients classified using ultrasound power Doppler (PD) and gray\u2010scale (GS) joint inflammation outcomes and the 28\u2010joint Disease Activity Score (DAS28).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Ultrasound erosion scores were compared between (a) patients in group 1 (PD positive and GS\u00a0\u2265\u00a0median score), group 2 (PD negative and GS\u00a0\u2265\u00a0median score) and group 3 (PD positive and GS\u00a0&lt;\u00a0median score) vs group 4 (PD negative and GS\u00a0&lt;\u00a0median score) and (b) patients with high, moderate and low DAS28 scores vs those in DAS28 remission. Comparative analyses were performed using the 2\u2010sample Student's <jats:italic>t<\/jats:italic> test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 1080 joints and 1800 joint recesses from 36 joints scanned in 30 RA adult patients (mean DAS28, 3.58; mean disease duration, 70.3\u00a0months) in this cross\u2010sectional study. The mean and 95% CI ultrasound erosion scores were significantly higher (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.026) for groups 1 (9.75, 6.69\u201012.81) vs 4 (3.4, 1.11\u20105.69) with a difference (95% CI) of 6.35 (0.78\u201011.83), but not significantly different (<jats:italic>P<\/jats:italic> values all &gt;\u00a0.05) for (a) groups 2 and 3 vs 4 and (b) patients with high, moderate and low DAS28 scores vs those in DAS28 remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Severity of ultrasound\u2010detected bone erosions was significantly greater when both positive PD and a greater degree of GS joint inflammation were present in RA. This association was not observed when either component was absent. Single time point ultrasound joint inflammation assessment \u2013 and not DAS28 \u2013 is reflective of joint damage severity in RA patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14013","type":"journal-article","created":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T09:18:46Z","timestamp":1604740726000},"page":"106-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Joint damage in rheumatoid arthritis: Lessons learned from an extended 36\u2010joint ultrasonography and 28\u2010joint Disease Activity Score assessments"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6944-8220","authenticated-orcid":false,"given":"York Kiat","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Singapore General Hospital  Singapore"},{"name":"Duke\u2010NUS Medical School  Singapore"},{"name":"Yong Loo Lin School of Medicine National 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