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Variation in genes involved in interferon pathways is expected to have a role in the etiology of these diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The potential association of a polymorphism in the <jats:italic>IL28RA<\/jats:italic> gene, involved in these pathways, with susceptibility to systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) and disease\u2010related phenotypes was investigated in 603 Brazilian individuals (354 well\u2010characterized SLE and RA patients, and 249 controls). <jats:italic>IL28RA<\/jats:italic> (rs4649203) variant was genotyped by TaqMan assay. Statistical analysis was performed including both diseases and a comprehensive list of patient clinical manifestations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The rs4649203\u2010G (minor) allele was associated with SLE and RA occurrence and was shown to be a risk factor for serositis and anemia among SLE patients as well as a protective factor for rheumatoid vasculitis and rheumatoid nodules in RA patients, suggesting an association with a milder form of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The <jats:italic>IL28RA<\/jats:italic> gene may contribute to SLE and RA susceptibility and to specific clinical manifestations of the diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14015","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T04:14:45Z","timestamp":1606968885000},"page":"49-55","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Interferon III\u2010related <i>IL28RA<\/i> variant is associated with rheumatoid arthritis and systemic lupus erythematosus and specific disease sub\u2010phenotypes"],"prefix":"10.1111","volume":"24","author":[{"given":"Manuela Nunes","family":"Drehmer","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Embryology and Genetics Federal University of Santa Catarina Florianopolis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Vaisam","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Embryology and Genetics Federal University of Santa Catarina Florianopolis 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