{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:41:18Z","timestamp":1789828878344,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The reported prevalence of peripheral neuropathy in systemic sclerosis (SSc) is variable between 0.01% to 28%, probably due to differences in sample size, study design and population. Our aim is to determine the prevalence of large fiber peripheral neuropathy in SSc and to identify any contributing factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A prospective cross\u2010sectional study of 60 SSc patients were evaluated for large fiber neuropathy using the modified clinical Total Neuropathy Score (cTNS) and nerve conduction study (NCS) of the upper and lower limbs. A combination of clinical (cTNS score\u00a0\u2265\u00a02) and NCS criteria (\u22652 abnormal nerves including 1 sural [symmetrical polyneuropathy] and NCS abnormalities consistent with individual nerves\/nerve roots [focal neuropathy]) was used to diagnose peripheral neuropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The majority had limited cutaneous subset (75%). Mean age was 55.73 (SD\u00a0\u00b1\u00a013.04) years and mean disease duration was 8.61 (SD\u00a0\u00b1\u00a08.09) years. Twenty\u2010two (36.7%) had combined clinical and NCS criteria for peripheral neuropathy, 14 (23.3%) with symmetrical polyneuropathy and 8 (13.3%) with focal neuropathy. Symmetrical polyneuropathy patients had significantly lower hemoglobin levels (11.2 vs. 12.35\u00a0g\/L; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.047). Serum vitamin B<jats:sub>12<\/jats:sub> levels were normal, therefore excluding vitamin B<jats:sub>12<\/jats:sub> deficiency. No other associations were found for both polyneuropathy and focal neuropathy with demography, co\u2010morbid diseases and SSc disease factors such as Raynaud's phenomenon and modified Rodnan skin score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Large fiber neuropathy is common in SSc patients, which could contribute to non\u2010lethal burden in SSc with sensory loss and muscle weakness. Apart from lower hemoglobin in polyneuropathy, there were no associations with disease\u2010specific features or co\u2010morbid diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14042","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T07:07:53Z","timestamp":1610694473000},"page":"347-354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Large fiber peripheral neuropathy in systemic sclerosis: A prospective study using clinical and electrophysiological definition"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3347-1362","authenticated-orcid":false,"given":"Jasmin","family":"Raja","sequence":"first","affiliation":[{"name":"Division of Rheumatology Department of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tharshannia","family":"Balaikerisnan","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letchumy Praba","family":"Ramanaidu","sequence":"additional","affiliation":[{"name":"Division of Neurology Department of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khean Jin","family":"Goh","sequence":"additional","affiliation":[{"name":"Division of Neurology Department of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880161110"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10439"},{"issue":"292","key":"e_1_2_6_4_1","first-page":"661","article-title":"Peripheral nerve dysfunction in scleroderma","volume":"80","author":"Schady W","year":"1991","journal-title":"Q J Med"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2206-6"},{"issue":"5","key":"e_1_2_6_6_1","first-page":"942","article-title":"Vasculitis in systemic sclerosis: association with Sjogren\u2019s syndrome and the CREST syndrome variant","volume":"14","author":"Oddis CV","year":"1987","journal-title":"J Rheumatol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70306-9"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.6.1641"},{"issue":"4","key":"e_1_2_6_9_1","first-page":"480","article-title":"Neurological manifestations in systemic sclerosis","volume":"11","author":"Lee P","year":"1984","journal-title":"J Rheumatol"},{"issue":"6","key":"e_1_2_6_10_1","first-page":"601","article-title":"Peripheral nervous system involvement in systemic sclerosis: the median nerve as target structure","volume":"14","author":"Lori S","year":"1996","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247422"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.038935"},{"key":"e_1_2_6_13_1","first-page":"57","article-title":"Ultrastructural changes of cutaneous nerves in scleroderma","volume":"34","author":"Badakov S","year":"1992","journal-title":"Folia Med (Plovdiv)"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh559"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530360094024"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22818"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1970.00480200032003"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204424"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.8.1660"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25029"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000149522.32823.EA"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.62.4.310"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2014.38.2.249"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203314552115"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.11.1612"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2013.05.002"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem251"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000000686"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14042","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.14042","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T07:19:38Z","timestamp":1693552778000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.14042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,11]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/1756-185X.14042"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.14042","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,11]]},"assertion":[{"value":"2020-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}