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Clinical and laboratory data of CAM and non\u2010CAM patients were compared. Logistic regression analysis was used to identify risk factors of CAM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of the 487 patients with DM\/CADM\/PM, 7.0% (34\/487) of patients were classified as CAM. Older age (53.91\u00a0\u00b1\u00a013.32 vs. 48.76\u00a0\u00b1\u00a014.34\u00a0years), heliotrope rash (61.8% vs. 41.9%), shawl sign (41.2% vs. 22.1%), V sign (58.8% vs. 38.6%) were observed significantly more commonly in patients with CAM than those without CAM (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Fever (17.7% vs. 37.8%), arthralgia\/arthritis (23.5% vs. 45.7%), interstitial lung disease (ILD, 38.2% vs 68.9%) were significantly less common in the CAM group than the non\u2010CAM group. Age at onset (odds ratio [OR] 1.036, 95% CI 1.001\u20101.072, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.042), shawl sign (OR 2.748, 95% CI 1.107\u20106.822, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.029), anti\u2010transition initiation factor (TIF)\u20101\u03b3 antibody (OR 4.012, 95% CI 1.268\u201012.687, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.018) were identified as the initial risk factors for the onset of CAM, and ILD was identified as a protective factor for CAM (OR 0.292, 95% CI 0.115\u20100.739, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.009). All\u2010cause mortality was significantly higher in CAM patients compared with non\u2010CAM patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The mortality of patients with CAM was higher than DM\/CADM\/PM patients without cancer. Malignancy should be screened in DM\/CADM\/PM patients especially with risk factors, including older age, shawl sign, anti\u2010TIF\u20101\u03b3 antibody, and lack of ILD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14046","type":"journal-article","created":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T08:26:01Z","timestamp":1608971161000},"page":"268-273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Risk factors for cancer\u2010associated myositis: A large\u2010scale multicenter cohort study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0134-218X","authenticated-orcid":false,"given":"Yimin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Beijing Key Laboratory for Rheumatism and Immune Diagnosis (BZ0135) Peking University People\u2019s Hospital Beijing 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People\u2019s Hospital of Jianyang City Jianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhou","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Beijing Key Laboratory for Rheumatism and Immune Diagnosis (BZ0135) Peking University People\u2019s Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Beijing Key Laboratory for Rheumatism and Immune Diagnosis (BZ0135) Peking University People\u2019s Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Ningde Hospital Affiliated Hospital of Fujian Medical University Ningde 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