{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:38:38Z","timestamp":1790890718405,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:00:00Z","timestamp":1610668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aims of this study were to estimate human leukocyte antigen (<jats:italic>HLA)\u2010B<\/jats:italic> allele frequency, to identify alleles associated with ankylosing spondylitis (AS), and to explore manifestations in various <jats:italic>HLA\u2010B*27<\/jats:italic> in Thai AS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cross\u2010sectional study. Thai patients older than 18\u00a0years with diagnosed AS according to modified New York criteria who visited Siriraj Hospital (Bangkok, Thailand) were consecutively enrolled. <jats:italic>HLA\u2010B<\/jats:italic> alleles were determined by reverse sequence\u2010specific oligonucleotide assays, and were assigned at a 4\u2010digit resolution. <jats:italic>HLA\u2010B<\/jats:italic> alleles of 334 unrelated healthy Thai donors who participated in a previous phase 2b dengue vaccine clinical trial were included as controls. Odds ratio (OR) and Fisher's exact test were used to estimate association between allele and AS. The <jats:italic>P<\/jats:italic> value significance threshold was calculated according to Bonferroni.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 88 patients who were recruited, 34 <jats:italic>HLA\u2010B<\/jats:italic> alleles were identified, and all patients were heterozygous. The prevalence of <jats:italic>HLA\u2010B*27<\/jats:italic> was 89.8%, and 4 alleles of <jats:italic>HLA\u2010B*27<\/jats:italic> were identified. <jats:italic>HLA\u2010B*27:04<\/jats:italic> (OR: 39.4, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001) and <jats:italic>HLA\u2010B*27:05<\/jats:italic> (OR: 13.8, <jats:italic>P\u00a0=\u00a0<\/jats:italic>.0011) were associated with AS. In contrast, <jats:italic>HLA\u2010B*27:06<\/jats:italic> was not found to be associated with AS (OR: 0.4, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.241). AS patients carrying <jats:italic>HLA\u2010B*27:04<\/jats:italic> were more likely to have enthesitis and younger age at onset than those carrying <jats:italic>HLA\u2010B*27:05<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>HLA\u2010B*27:04<\/jats:italic> and <jats:italic>HLA\u2010B*27:05<\/jats:italic> were both found to be strongly associated with Thai AS. <jats:italic>HLA\u2010B*27:06<\/jats:italic> showed a neutral allele for Thai AS. AS patients with <jats:italic>HLA\u2010B*27:04<\/jats:italic> had more enthesitis and younger age at onset than those with <jats:italic>HLA\u2010B*27:05<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14055","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T23:28:41Z","timestamp":1610753321000},"page":"411-417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>HLA\u2010B*27:04<\/i> associated with enthesitis and younger age of onset, and HLA\u2010B allele profile in patients with ankylosing spondylitis in Thailand: A cross\u2010sectional study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4253-9229","authenticated-orcid":false,"given":"Praveena","family":"Chiowchanwisawakit","sequence":"first","affiliation":[{"name":"Division of Rheumatology Department of Medicine Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3611-5718","authenticated-orcid":false,"given":"Manop","family":"Pithukpakorn","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics Department of Medicine Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komon","family":"Luangtrakool","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parichart","family":"Permpikul","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Faculty of Medicine Siriraj Hospital Mahidol University Bangkok 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