{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:56:46Z","timestamp":1773799006889,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T00:00:00Z","timestamp":1614297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to investigate relapse rates in azathioprine (AZA) maintenance therapy at different doses in Beh\u00e7et's disease (BD) with venous involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Clinical records of patients who met the diagnostic criteria of International Study Group (ISG) for BD, were diagnosed with venous involvement of BD for at least 6\u00a0months and sustained clinical remission with AZA for at least 3\u00a0months were analyzed retrospectively. The analysis cohort was divided into 2 groups based on AZA dose (Group A: \u2265 2\u00a0mg\/kg\/d and Group B: &lt;2\u00a0mg\/kg\/d). Relapse was defined as requiring another antirheumatic\/immunosuppressive drug or more than dose of 10\u00a0mg\/d of prednisolone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 78 patients who were included into the study, there was no significant difference between the 2 groups in terms of age, gender and clinical characteristics. Mean relapse\u2010free survival time was found to be higher in group A compared to group B (111.6\u00a0\u00b1\u00a011.2, 95% CI 89.5\u00a0\u00b1\u00a0133.8 versus 51.5\u00a0\u00b1\u00a06.1, 95% CI 39.5\u00a0\u00b1\u00a063.4 months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Relapse\u2010free survival rate was less in the group receiving low\u2010dose AZA and shows the importance of effective dose of AZA in maintenance therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14075","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T05:51:01Z","timestamp":1614405061000},"page":"562-566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparison of relapse rates in Beh\u00e7et\u2019s disease with venous involvement on different doses of azathioprine therapy, a retrospective observational study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4341-9736","authenticated-orcid":false,"given":"Sinem","family":"Girgin","sequence":"first","affiliation":[{"name":"Bakirkoy Dr. Sadi Konuk Training and Research Hospital Health Sciences University Istanbul Turkey"},{"name":"Hacettepe University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5703-6739","authenticated-orcid":false,"given":"Seda","family":"Yurumez","sequence":"additional","affiliation":[{"name":"Ankara Numune Training and Research Hospital Health Sciences University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2582-7445","authenticated-orcid":false,"given":"Ahmet","family":"Omma","sequence":"additional","affiliation":[{"name":"Ankara Numune Training and Research Hospital Health Sciences University Ankara 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