{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T07:28:04Z","timestamp":1772522884221,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T00:00:00Z","timestamp":1612656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Recently, multisystem inflammatory syndrome in children (MIS\u2010C) has been recognized in association with coronavirus disease 2019 as a cytokine storm syndrome. MIS\u2010C presents with symptoms similar to Kawasaki disease and macrophage activation syndrome (MAS). We aimed to better understand this cytokine storm syndrome by comparing the initial laboratory findings of MIS\u2010C and MAS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who were diagnosed with MAS due to systemic juvenile idiopathic arthritis in our clinic between March 2002 and November 2020 and with MIS\u2010C between 20 September and 20 October 2020 were enrolled into the study. The medical files of all patients were reviewed retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 13 MAS (9 boys, 4 girls) and 26 MIS\u2010C (16 boys,10 girls) patients were included in the study. Hemoglobin, absolute neutrophil and lymphocyte counts, C\u2010reactive protein (CRP), ferritin, fibrinogen and lactate dehydrogenase (LDH) levels showed significant differences between the two groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Patients with MAS had lower hemoglobin (10.10\u00a0g\/dL) and fibrinogen (2.72\u00a0g\/dL), but higher ferritin (17\u00a0863\u00a0mg\/dL) and LDH (890.61\u00a0U\/L) at the time of diagnosis. Patients with MIS\u2010C had higher absolute neutrophil count (12\u00a0180\/mm<jats:sup>3<\/jats:sup>) and CRP (194.23\u00a0mg\/dL) values, but lower absolute lymphocyte count (1140\/mm<jats:sup>3<\/jats:sup>) at the time of diagnosis. Left ventricle ejection fraction was significantly lower in the MIS\u2010C group in echocardiographic evaluation (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ferritin, hemoglobin, LDH, and fibrinogen levels were significantly changed in MAS compared with MIS\u2010C. However, patients with MIS\u2010C have more severe signs than MAS, such as cardiac involvement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14078","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T19:22:34Z","timestamp":1612812154000},"page":"542-547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Comparison of baseline laboratory findings of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis and multisystem inflammatory syndrome in children"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0306-7473","authenticated-orcid":false,"given":"Fatma","family":"Ayd\u0131n","sequence":"first","affiliation":[{"name":"Division of Pediatric Rheumatology Department of Pediatrics Ministry of Health Ankara City Hospital Ankara 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