{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:20:43Z","timestamp":1764937243318,"version":"3.40.5"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100013018","name":"Hospital for Special Surgery","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Prevalence of sacroiliitis in Crohn's disease (CD) is variable depending on defining criteria. This study utilized standardized sacroiliac joint (SIJ) magnetic resonance imaging (MRI) to identify sacroiliitis in CD patients and its association with clinical and serological markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive adult subjects with CD prospectively enrolled from an inflammatory bowel disease clinic underwent SIJ MRI. Data collected included CD duration, history of joint\/back pain, human leukocyte antigen\u2010B27 status, Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Disease Activity Index, Harvey Bradshaw Index (HBI) for activity of CD, Ankylosing Spondylitis Disease Activity Score, and various serologic markers of inflammation. Three blinded readers reviewed MRIs for active and structural lesions according to the Spondyloarthritis Research Consortium of Canada modules.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010three CD patients were enrolled: 76% female, 80% White, median age 36.4\u00a0years (interquartile range 27.2\u201049.0), moderate CD activity (mean HBI 8.8\u00a0\u00b1\u00a0SD 4.5). Nineteen subjects (58%) reported any back pain, 13 of whom had inflammatory back pain. Four subjects (12%) showed sacroiliitis using global approach and 6 (18%) met Assessment of SpondyloArthritis international Society MRI criteria of sacroiliitis. Older age (mean 51.2\u00a0\u00b1\u00a0SD 12.5 vs. 37.2\u00a0\u00b1\u00a014; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04), history of dactylitis (50.0% vs. 3.4%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03) and worse BASMI (4.1\u00a0\u00b1\u00a00.7 vs. 2.4\u00a0\u00b1\u00a00.8, <jats:italic>P<\/jats:italic>\u00a0\u2264\u00a0.001) were associated with MRI sacroiliitis; no serologic measure was associated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There were 12%\u201018% of CD patients who had MRI evidence of sacroiliitis, which was not associated with back pain, CD activity or serologic measures. This data suggests that MRI is a useful modality to identify subclinical sacroiliitis in CD patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14081","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T00:48:12Z","timestamp":1612572492000},"page":"582-590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Utility of magnetic resonance imaging in Crohn's associated sacroiliitis: A cross\u2010sectional study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0107-2770","authenticated-orcid":false,"given":"Fardina","family":"Malik","sequence":"first","affiliation":[{"name":"Division of Rheumatology Department of Medicine NYU School of Medicine New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Scherl","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine Jill Roberts Institute for Research in Inflammatory Bowel Disease New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Weber","sequence":"additional","affiliation":[{"name":"Danish Hospital for Rheumatic Diseases University Hospital of Southern Denmark S\u00f8nderborg Denmark"},{"name":"Department of Regional Health Research University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Carrino","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Hospital for Special Surgery and Weill Cornell Medicine New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeline","family":"Epsten","sequence":"additional","affiliation":[{"name":"Rush Medical School Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Wichuk","sequence":"additional","affiliation":[{"name":"University of Alberta Edmonton AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne J.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Copenhagen Center for Arthritis Research Rigshospitalet\u2010Glostrup University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Paschke","sequence":"additional","affiliation":[{"name":"CARE Arthritis Edmonton AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Schwartzman","sequence":"additional","affiliation":[{"name":"Department of Medicine Weill Cornell Medicine New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Kroeber","sequence":"additional","affiliation":[{"name":"Danish Hospital for Rheumatic Diseases University Hospital of Southern Denmark S\u00f8nderborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter P.","family":"Maksymowych","sequence":"additional","affiliation":[{"name":"University of Alberta Edmonton AB Canada"},{"name":"CARE Arthritis Edmonton AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randy","family":"Longman","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine Jill Roberts Institute for Research in Inflammatory Bowel Disease New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa A.","family":"Mandl","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Medicine Hospital for Special Surgery, and Weill Cornell Medicine New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1016\/j.rdc.2012.09.002"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1002\/acr.21621"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1016\/j.cgh.2007.07.012"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1136\/annrheumdis-2016-210747"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1136\/ard.2009.108233"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1002\/art.39612"},{"issue":"7","key":"e_1_2_8_8_1","first-page":"1109","article-title":"Clinical features and prognosis of patients with possible ankylosing spondylitis. 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