{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:52:33Z","timestamp":1790855553388,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T00:00:00Z","timestamp":1614297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim of the work<\/jats:title><jats:p>To identify the role of serum IL\u201013, and its receptor subunit expressions as a serologic marker of rheumatoid arthritis (RA)\u2010associated ILD (RA\u2010ILD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Fifty RA patients with ILD and 50 RA patients without ILD were examined, in addition to 50 controls. Disease Activity Score in 28 joints (DAS\u201028), the Health Assessment Questionnaire (HAQ), and medication history were evaluated. ESR, CRP, RF, Anti\u2010CCP, Serum Krebs von den Lungen\u20106 (KL\u20106), surfactant protein D (SP\u2010D) levels, Interleukin 13 and its receptors (IL\u201013 R\u03b11 and L\u201013 R\u03b12), and mRNA relative expression levels in peripheral blood mononuclear cells (PBMCs) were measured. High\u2010resolution computed tomography (HRCT) scores were used with all RA patients with interstitial lung disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age, percent of male affection, duration of the disease, DAS28 and MHAQ were significantly higher in the RA\u2013ILD group than in the RA\u2013no ILD group. ESR, CRP, RF, anti\u2010CCP, serum KL\u20106, SP\u2010D, IL\u201013 levels, IL\u201013 R\u03b11and IL\u201013 R\u03b12 mRNA expressions were significantly increased in RA patients compared to controls; in addition, their levels were significantly higher in the RA\u2013ILD group than in the RA\u2013no ILD group. Serum IL\u201013 levels and IL\u201013 R\u03b11and IL\u201013 R\u03b12 were positively correlated with RF, Anti\u2010CCP, KL\u20106, SP\u2010D, and the HRCT score (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum IL\u201013 and its receptor subunit expressions are useful biomarkers which can be used in detecting severity of the interstitial lung disease in RA patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14084","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T05:52:15Z","timestamp":1614405135000},"page":"591-598","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Identification of serum interleukin\u201013 and interleukin\u201013 receptor subunit expressions: Rheumatoid arthritis\u2013associated interstitial lung 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