{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:31:25Z","timestamp":1747182685831,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011645","name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","doi-asserted-by":"publisher","award":["KMUH102\u20102M14"],"award-info":[{"award-number":["KMUH102\u20102M14"]}],"id":[{"id":"10.13039\/501100011645","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p><jats:italic>F11R<\/jats:italic> gene encodes junctional adhesion molecule\u2010A protein (JAM\u2010A), which is expressed in various types of cells and is involved in leukocyte extravasation during inflammation. Sj\u00f6gren's syndrome (SS) is a chronic systemic inflammatory disease that involves lymphocytes invasion of exocrine glands. <jats:italic>F11R<\/jats:italic> has been studied in autoimmune diseases, but any association between <jats:italic>F11R<\/jats:italic> and SS has not yet been investigated. Therefore, experiments were undertaken to examine the relationships among <jats:italic>F11R<\/jats:italic> gene polymorphism, messenger RNA (mRNA) expression and SS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three hundred and twenty\u2010nine patients with SS, and 223 healthy controls were enrolled in their recruitment from the Kaohsiung Medical University Hospital. Genomic DNA was extracted from peripheral blood mononuclear cells and gene polymorphisms were genotyped by TaqMan real\u2010time polymerase chain reaction (PCR). F11R mRNA expression was quantitated by quantitative real\u2010time PCR with TaqMan Gene Expression Assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our study showed the genotype \u2010688A\/C (rs6695707) was not found in relation to SS patients. The odds ratio of \u2010436A\/G (rs12567886) genotype was notably associated with less susceptibility of SS in human leukocyte antigen (<jats:italic>HLA<\/jats:italic>)\u2010<jats:italic>DR2<\/jats:italic> negative and <jats:italic>HLA\u2010DR3<\/jats:italic> negative individuals. F11R mRNA expression was lower in SS patients than in the cells of healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The result indicated that G allele of \u2010436A\/G genotype has the potential protective effect against SS disease condition. F11R mRNA was expressed significantly lower in SS patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14095","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T12:15:38Z","timestamp":1617020138000},"page":"681-686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of F11R polymorphisms and gene expression with primary Sj\u00f6gren\u2019s syndrome patients"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7318-5152","authenticated-orcid":false,"given":"Tzu\u2010Jung","family":"Fang","sequence":"first","affiliation":[{"name":"Division of Geriatrics and Gerontology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan"},{"name":"Graduate Institute of Clinical Medicine College of Medicine Kaohsiung Medical University Kaohsiung 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