{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:23Z","timestamp":1787013743720,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:00:00Z","timestamp":1618531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013822","name":"Kurdistan University Of Medical Sciences","doi-asserted-by":"publisher","award":["1394.87"],"award-info":[{"award-number":["1394.87"]}],"id":[{"id":"10.13039\/501100013822","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Osteoarthritis (OA) is the most common chronic joint disorder, resulting from the breakdown of joint cartilage. It occurs in the knees, hands, and hips, leading to pain, stiffness, inflammation, and swelling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this study, 100 hand and knee OA patients, meeting the American College of Rheumatology criteria were included in the case group, and 100 healthy individuals were allocated to the control group. Blood samples were collected from the participants. After DNA extraction, genotyping was carried out for\n                      <jats:italic>GDF5<\/jats:italic>\n                      rs143383 C\/T polymorphism by allele\u2010specific polymerase chain reaction (ASPCR) and for D\u2010repeat alleles of asporin\n                      <jats:styled-content>(<\/jats:styled-content>\n                      ASPN) by conventional PCR assay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results showed that the frequency of the D14 allele of ASPN was significantly higher than other alleles in the case group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0001). Also, the frequency of the D14 allele among women was significantly higher than in men (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.004). Moreover, the frequency of the TT allele in\n                      <jats:italic>GDF5<\/jats:italic>\n                      rs143383 C\/T polymorphism was significantly higher than the CC and CT alleles in the case group, compared with the control group (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a0.001). A significant difference was found between the TT allele and other alleles in female and male patients compared with the control group (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a0.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The D14 allele of the ASPN gene and TT allele of the\n                      <jats:italic>GDF5<\/jats:italic>\n                      gene (rs143383\u00a0+\u00a0104T\/C) are associated with hand and knee OA in the Kurdish population, indicating that these alleles could be risk factors for OA, at least in our populations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.14097","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T20:55:16Z","timestamp":1618606516000},"page":"694-700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Frequency of Growth Differentiation Factor 5 rs143383 and asporin D\u2010repeat polymorphisms in patients with hand and knee osteoarthritis in Kurdistan province, Iran"],"prefix":"10.1111","volume":"24","author":[{"given":"Nasrin","family":"Moghimi","sequence":"first","affiliation":[{"name":"Cancer &amp; Immunology Research Center Research Institute for Health Development Kurdistan University of Medical Sciences Sanandaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherko","family":"Nasseri","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center Research Institute for Health Development Kurdistan University of Medical Sciences Sanandaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzad","family":"Ghafouri","sequence":"additional","affiliation":[{"name":"Cancer &amp; Immunology Research Center Research Institute for Health Development Kurdistan University of Medical Sciences Sanandaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1833-4928","authenticated-orcid":false,"given":"Ali","family":"Jalili","sequence":"additional","affiliation":[{"name":"Cancer &amp; Immunology Research Center Research Institute for Health Development Kurdistan University of Medical Sciences Sanandaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380817"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2005.02.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/2005"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm174"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2010.03.001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12312"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12809"},{"key":"e_1_2_8_9_1","unstructured":"Pfleger2 ADWB.Burden of major musculoskeletal conditions. 2000 \u20132010."},{"issue":"12","key":"e_1_2_8_10_1","first-page":"2507","article-title":"Prevalence of symptomatic knee, hand, and hip osteoarthritis in Greece. 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