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The present article aimed to provide an insight into the potential pathophysiological mechanisms underlying exercise\u2010related benefits in myositis. A systematic search was performed on PubMed\/MEDLINE, Scopus, Web of Science, and Google Scholar using the following keywords and their combinations: \u201cidiopathic inflammatory myopathy\u201d, \u201cinflammatory myopathy\u201d, \u201cmyositis\u201d, \u201cpolymyositis\u201d, \u201cdermatomyositis\u201d, \u201cinclusion body myositis\u201d, and \u201cexercise\u201d. Current literature indicates that exercising has impact on both immune and non\u2010immune pathways in patients with IIM. Exercise\u2010related benefits include (a) increased mitochondrial biogenesis\/enzyme activity, (b) reconditioning of immune\/inflammatory pathways, (c) decreased endoplasmic reticulum stress, (d) modulation of gene expression, (e) increased protein synthesis and cytoskeletal remodeling, and (f) decreased muscle fibrosis and non\u2010muscle area infiltrates. With its certain benefits, exercise stands as a precious non\u2010pharmacological treatment option for patients with IIM.<\/jats:p>","DOI":"10.1111\/1756-185x.14104","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T13:29:37Z","timestamp":1617283777000},"page":"896-903","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The pathophysiological effects of exercise in the management of idiopathic inflammatory myopathies: A scoping review"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6517-5969","authenticated-orcid":false,"given":"Ilke","family":"Coskun Benlidayi","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Cukurova University Faculty of Medicine  Adana 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