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Metformin, a widely used antidiabetic medication, has anti\u2010proliferative, immunomodulating and anti\u2010fibrotic activities. The purpose of our study is to determine the therapeutic efficacy of secukinumab and metformin on bleomycin (BLM) induced dermal fibrosis. Fifty Balb\/c female mice were divided into 5 groups: (group 1 control, 2 sham, 3 secukinumab, 4 metformin and 5 secukinumab\u00a0+\u00a0metformin). The mice in the control group received 100\u00a0\u03bcL phosphate\u2010buffered saline (PBS), while the mice in other groups received 100\u00a0\u03bcL (100\u00a0\u03bcg) BLM in PBS subcutaneously (sc) every day for 4\u00a0weeks. In addition, mice in groups 3 and 5 received secukinumab at a dose of 10\u00a0mg\/kg\/wk sc, and mice in the groups 4 and 5 received oral metformin 50\u00a0mg\/kg\/d for 28\u00a0days. All groups of mice were sacrificed at the end of the 4th week and tissue samples were taken for analysis. In addition to histopathological analysis, skin tissue messenger RNA (mRNA) expressions of IL\u201017 and collagen 3A were measured by real\u2010time polymerase chain reaction. Repeated BLM injections had caused dermal fibrosis. In addition, the mRNA expressions of IL\u201017 and collagen 3A were increased in the BLM group. Secukinumab and metformin ameliorated dermal fibrosis. They decreased dermal thickness and tissue IL\u201017A and collagen 3A mRNA levels. Secukinumab and metformin exhibit anti\u2010fibrotic effects in the BLM\u2010induced dermal fibrosis.<\/jats:p>","DOI":"10.1111\/1756-185x.14114","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T12:17:51Z","timestamp":1617970671000},"page":"795-802","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Secukinumab and metformin ameliorate dermal fibrosis by decreasing tissue interleukin\u201017 levels in bleomycin\u2010induced dermal fibrosis"],"prefix":"10.1111","volume":"24","author":[{"given":"Ahmet","family":"Karatas","sequence":"first","affiliation":[{"name":"Department of Rheumatology Faculty of Medicine Firat University Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cigdem","family":"Celik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Eleskirt State Hospital Agri 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