{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:08:23Z","timestamp":1765004903031,"version":"3.40.5"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the associations between exercise capacity (EC), cardiovascular (CV) risk factors and disease\u2010related variables in axial spondyloarthritis (AxSpA) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional controlled study, CV risk profile data, physical activity, 10\u2010year CV event risk estimated by the Framingham model and Ankylosing Spondylitis Disease Activity Score \u2013 C\u2010reactive protein were recorded. A maximal treadmill exercise test by Bruce protocol was administered. Analyses of covariance were performed with adjustments for age, smoking status and physical activity level. Linear regression analysis was performed to study the association between EC and related CV risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010eight patients and 38 age\u2010gender matched controls were recruited between May and October 2014. Patients had significantly lower EC than controls (MD 2.2; metabolic equivalents 0.91\u20103.49; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). The difference remained significant after adjustments (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). There were significant correlations between EC and age, 10\u2010year CV event risk, body mass index (BMI) and waist circumference for patients and controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001 and <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05, respectively). There was a significant relationship between EC and total cholesterol, triglycerides and heart rate recovery (HRR) in patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.04, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001 and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006, respectively). High\u2010density lipoprotein \u2010 cholesterol was significantly higher, and BMI was significantly lower in nonradiographic AxSpA patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.026 and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03 respectively). Age and triglyceride levels were found as the significant predictors for EC in the AxSpa group (for age <jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u2212.105, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.003; for triglycerides <jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u2212.016 <jats:italic>P<\/jats:italic>\u00a0=\u00a0.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Exercise capacity was significantly lower and attenuated HRR was significantly associated with low EC and high 10\u2010year CV event risk in AxSpA patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14155","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T10:55:06Z","timestamp":1623840906000},"page":"1014-1023","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exercise capacity in axial spondyloarthritis and associated factors: A cross\u2010sectional controlled study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2578-8661","authenticated-orcid":false,"given":"Ebru","family":"K\u00f6seo\u011flu Tohma","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Gazi University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0696-5834","authenticated-orcid":false,"given":"Zafer","family":"G\u00fcnendi","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Gazi University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zden","family":"\u00d6zyemi\u015f\u00e7i Ta\u015fk\u0131ran","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Ko\u00e7 University School of Medicine \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6nen","family":"Mengi","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University Hospital Mu\u011fla Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nesrin","family":"Demirsoy","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Gazi University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihal","family":"Ta\u015f","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Gazi University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60635-7"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37803"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000461"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.681"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJR.0b013e3283312e94"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21926"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20110137"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-012-0270-6"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12347"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(99)90036-7"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-015-3339-5"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.104018"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000078924.61453.FB"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4279"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.699579"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.100826"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3283470f23"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.138594"},{"issue":"6","key":"e_1_2_12_20_1","first-page":"323","article-title":"Exercise testing of patients with coronary heart disease. 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