{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:47:47Z","timestamp":1776872867944,"version":"3.51.2"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to detect macrovascular findings in systemic sclerosis (SSc) by means of color Doppler ultrasonography (CDUS) and to evaluate the relationship between the laboratory and clinical findings in the setting of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cross\u2010sectional study. Eighty\u2010eight patients were included in the study. CDUS examinations of the bilateral carotid, vertebral, and peripheral arteries were performed. The presence of macrovascular involvement was investigated and recorded, and its relationships with the clinical, laboratory, and cardiovascular risk factors were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An atheromatous plaque was found in 67.7% of the 1936 arteries examined by CDUS. Of these 1936 arteries, 37.4% demonstrated a narrowing of the intraluminal diameter. On the other hand, the carotid intima\u2010media thickness (CIMT) was found to have increased in 55.7% of the patients. This increase was found to be statistically correlated with disease duration, the modified Rodnan Skin Thickness Score, and the Medsger Disease Activity Score. But no relation existed with the disease subtype, age, or cardiovascular risk factors. Arterial occlusion was detected in 10 patients. An association was found between the CIMT values and arterial occlusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study, we examined the arteries by means of CDUS, and we detected structural alterations in the peripheral and carotid arteries. We witnessed that these macrovascular changes had a close association with certain features of SSc. We think there is a need for broader prospective studies in order to evaluate the contribution of these factors to the macrovascular changes stated in the article.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14158","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T13:15:33Z","timestamp":1623935733000},"page":"954-962","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Arterial evaluation of systemic sclerosis patients with Doppler ultrasound: What did we find?"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4661-787X","authenticated-orcid":false,"given":"Suade Ozlem","family":"Badak","sequence":"first","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Adana City Training and Research Hospital Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bozkurt","family":"Gulek","sequence":"additional","affiliation":[{"name":"Department of Radiology Adana City Training and Research Hospital Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3570-875X","authenticated-orcid":false,"given":"Esra","family":"Kayacan Erdogan","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Adana City Training and Research Hospital Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hulya","family":"B\u0131nokay","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Cukurova University Faculty of Medicine Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eren","family":"Erken","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Adana Ac\u0131badem Hospital Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9092687"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0386-4"},{"issue":"1","key":"e_1_2_10_4_1","first-page":"8","article-title":"Cardiovascular disease in systemic sclerosis","volume":"3","author":"Cannarile F","year":"2015","journal-title":"Ann Transl Med"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12566"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.018283"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2009.01453.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.181311"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2016.12.020"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.066068"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204424"},{"issue":"2","key":"e_1_2_10_12_1","first-page":"202","article-title":"Scleroderma (systemic sclerosis): classification, subsets and pathogenesis","volume":"15","author":"LeRoy EC","year":"1988","journal-title":"J Rheumatol"},{"issue":"2","key":"e_1_2_10_13_1","first-page":"167","article-title":"Prevalence of macrovascular disease in systemic sclerosis","volume":"32","author":"Othman MOM","year":"2005","journal-title":"Egypt. 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