{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T06:34:30Z","timestamp":1774852470277,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the impact of family history of autoimmune diseases (FHADs) on the clinical characteristics and outcome of juvenile idiopathic arthritis (JIA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed children with JIA seen in 7 pediatric rheumatology clinics from 6 Arab countries. All included patients met the International League of Associations for Rheumatology classification criteria for JIA and had a disease duration greater than 1 year. Data were collected at the last follow\u2010up visit and comprised clinical findings, including FHADs. Disease activity and disease damage were assessed by Juvenile Arthritis Multidimensional Assessment Report, and juvenile arthritis damage index (JADI) respectively. Disease activity was categorized as remission off treatment, remission on treatment, or active disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 349 (224 females) JIA patients with a disease duration of 5 (interquartile range 2.9\u20107.5) years were included. The most frequent JIA categories were polyarticular JIA and oligoarticular JIA, followed by systemic JIA. There were 189 patients with FHADs and 160 patients without FHADs. The most frequent FHADs were diabetes mellitus (21.2%), JIA (18.5%), rheumatoid arthritis (12.7%). Among patients with FHADs, 140\/189 (74.1%) achieved clinical remission, while 131\/160 (81.9%) patients without FHDs had clinical remission (odds ratio [OR]\u00a0=\u00a01.2, 95% CI 0.97\u20101.5). Rate of consanguinity, enthesitis\u2010related arthritis (ERA) and psoriatic arthritis were higher in patients with FHADs (OR\u00a0=\u00a00.6, 95% CI 0.4\u20100.9 and OR\u00a0=\u00a01.2, 95% CI 1.1\u20101.4). Also, articular JADI correlated significantly with presence of FHADs (OR\u00a0=\u00a01.1, 95% CI 1.0\u20101.1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study shows that autoimmune diseases cluster within families of patients with JIA with a high proportion of ERA and psoriatic arthritis. JIA patients with FHADs are likely to have more disease damage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14167","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T11:30:27Z","timestamp":1624966227000},"page":"1080-1085","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Familial aggregation of juvenile idiopathic arthritis with other autoimmune diseases: Impact on clinical characteristics, disease activity status and disease damage"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0142-6698","authenticated-orcid":false,"given":"Sulaiman M.","family":"Al\u2010Mayouf","sequence":"first","affiliation":[{"name":"King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abeer","family":"Alrasheedi","sequence":"additional","affiliation":[{"name":"King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iman","family":"Almsellati","sequence":"additional","affiliation":[{"name":"Tripoli Children Hospital Tripoli Libya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soad","family":"Hashad","sequence":"additional","affiliation":[{"name":"Tripoli Children Hospital Tripoli Libya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khulood","family":"Khawaja","sequence":"additional","affiliation":[{"name":"Al\u2010Mafraq Hospital Abu Dhabi United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reem","family":"Abdwani","sequence":"additional","affiliation":[{"name":"Sultan Qaboos University Hospital Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samia","family":"AlHashim","sequence":"additional","affiliation":[{"name":"King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Muzaffer","sequence":"additional","affiliation":[{"name":"King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hala","family":"Lotfy","sequence":"additional","affiliation":[{"name":"Medical School Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora","family":"Almutairi","sequence":"additional","affiliation":[{"name":"AlSabah Hospital Kuwait City Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.180168"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23177"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000094"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2014.889119"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4755-6-17"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(19)30188-9"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1571-6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205265"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-016-0075-7"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13092"},{"issue":"2","key":"e_1_2_6_12_1","first-page":"310","article-title":"Autoimmune endocrine disorders and coeliac disease in children and adolescents with juvenile idiopathic arthritis and rheumatic fever","volume":"31","author":"Robazzi T","year":"2013","journal-title":"Clin Exp Rheumatolo"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2013.09.003"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216263"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.170834"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpam.2020.11.005"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2012.02658.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2018.11.006"},{"issue":"5","key":"e_1_2_6_19_1","first-page":"569","article-title":"The effect of positive history of autoimmunity in juvenile idiopathic arthritis characteristics; 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