{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T17:24:12Z","timestamp":1778261052431,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T00:00:00Z","timestamp":1625443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sj\u00f6gren's syndrome (SS) has been a well\u2010documented cause of secondary membranous nephropathy (MN); however, the prevalence is quite low. Since primary MN is also a common disease in middle age, whether MN is secondary to SS or just coincidence remains uncertain. The detection of phospholipase A2 receptor (PLA2R), which is most often positive in idiopathic MN, has been rarely reported in such cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively studied 13 cases diagnosed with MN and SS in Huashan Hospital between 2009 and 2020, and performed PLA2R detection. We also review the literature by searching in the PubMed database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 13 patients, 8 were found to be PLA2R\u2010positive and 5 were negative. Nine patients were female. All but 1 patients had normal renal function at the time of biopsy. All patients showed positive anti\u2010nuclear antibody and anti\u2010SSA. Two of the 8 PLA2R\u2010positive patients showed positive anti\u2010SSB and 1\/8 had mild hypocomplementemia, while all 5 PLA2R\u2010negative patients had positive anti\u2010SSB and 3 showed hypocomplementemia. Renal biopsy revealed focal MN and markedly mesangial hyperplasia in PLA2R\u2010negative patients. Mesangial electron deposits were observed in 1 PLA2R\u2010positive patient in small amounts, and in 3 PLA2R\u2010negative patients with 2 in large amounts. During follow\u2010up, 2 patients in the PLA2R\u2010negative group presented with progressively decreasing serum complement levels, and another one was diagnosed with systemic lupus erythematosus (SLE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with both MN and SS, PLA2R\u2010negative MN should be considered as a secondary form. Careful screen for SLE is necessary in these patients during follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14168","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T11:44:21Z","timestamp":1625485461000},"page":"1086-1094","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Sj\u00f6gren\u2019s syndrome complicated with membranous nephropathy, a cause or coincidence?"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2556-7604","authenticated-orcid":false,"given":"Ruiying","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Nephrology Huashan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Nephrology Beijing Chao\u2010Yang Hospital Capital Medical University Beijing 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