{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T18:11:21Z","timestamp":1782756681432,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,11]],"date-time":"2021-07-11T00:00:00Z","timestamp":1625961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010780","name":"Celltrion Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate clinical characteristics and natural history of non\u2010radiographic axial spondyloarthritis (nr\u2010axSpA) using KOrean Nonradiographic Axial SPondyloArthritis (KONASPA) data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were collected from 11 centers in South Korea. A total of 278 patients with nr\u2010axSpA from January 2018 to July 2020 were included. Demographic data, clinical features, comorbidities, disease activity, medications, and laboratory results were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age at symptom onset was 28.2\u00a0\u00b1\u00a014.2\u00a0years. Of 278 patients, 152 (54.7%) were male. Mean Bath Ankylosing Spondylitis Disease Activity Index at diagnosis was 3.5\u00a0\u00b1\u00a02.1. Dyslipidemia was the most common comorbidity (8.4%), followed by hypertension (6.1%). Mean age at diagnosis of nr\u2010axSpA was older in female patients than in male patients (31.8\u00a0\u00b1\u00a015.8\u00a0years vs 24.9\u00a0\u00b1\u00a012.0\u00a0years, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Enthesitis and uveitis were more frequently found in female patients than in male patients. Thirty\u2010one (11.1%) participants with nr\u2010axSpA progressed to ankylosing spondylitis. The median follow\u2010up duration was 48\u00a0months. In multivariable Cox regression analysis, age at symptom onset (hazard ratio [HR] 0.93, 95% confidence interval (CI) 0.88\u20100.97, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006), body mass index (BMI) (HR 1.24, 95% CI 1.06\u20101.44, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005) and sacroiliitis grade (HR 1.86, 95% CI 1.19\u20102.92, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006) were associated with progression to ankylosing spondylitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results of nationwide data revealed that women with nr\u2010axSpA showed a late disease onset and more extra\u2010articular manifestations than men. Young age at symptom onset, high BMI, and presence of radiographic sacroiliitis at diagnosis were risk factors for progression to AS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14175","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T06:11:33Z","timestamp":1626070293000},"page":"1137-1147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical characteristics of non\u2010radiographic axial spondyloarthritis: Results of the Korean Nonradiographic Axial SPondyloArthritis (KONASPA) data"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6227-681X","authenticated-orcid":false,"given":"Hyemin","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Soonchunhyang University Hospital Bucheon South 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