{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T03:04:36Z","timestamp":1772766276906,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The study aims to recognize the prevalence and possible risk factors of obstructive sleep apnea among individuals with rheumatoid arthritis (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched PubMed, Scopus, EMBASE, and Google scholar for potential studies published before the October 30, 2020. The study characteristics, obstructive sleep apnea (OSA) events, and various types of rheumatic diseases were extracted, and the meta\u2010analysis method was used to pool the estimates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified eight studies with 37\u00a0285 patients for this meta\u2010analysis. The overall pooled prevalence of OSA was 29.8% (95% confidence interval [CI] 15.2\u201046.7; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a099.6%) in the patients with RA. Age was higher in RA patients with OSA but this was not significant. Body mass index (BMI) was significantly associated with OSA in the RA population (standardized mean difference 1.08; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.044). Assessment based on the Berlin Questionnaire<jats:sup>\u00a9<\/jats:sup> for Sleep Apnea resulted in a more precise estimate of OSA prevalence with reduced heterogeneity (prevalence 45.3%; 95% CI 37.4\u201053.3; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a058.8%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prevalence of OSA among the RA cohort was 29.8% with significant heterogeneity. However, the prevalence was 45.3% when studies were restricted to the OSA diagnosis based on the Berlin questionnaire with very low heterogeneity. Higher BMI is the principal risk factor of OSA development in RA. Hence, controlling BMI could be a preventive strategy for OSA among RA patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14178","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T11:14:18Z","timestamp":1626693258000},"page":"1354-1361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Prevalence of obstructive sleep apnea among patients with rheumatoid arthritis and its association with age and body mass index: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"24","author":[{"given":"Bhaskar","family":"Thakur","sequence":"first","affiliation":[{"name":"Division of Biostatistics and Epidemiology Department of Molecular and Translational Medicine Paul L. Foster School of Medicine Texas Tech University Health Sciences Center El Paso El Paso Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Pathak","sequence":"additional","affiliation":[{"name":"Division of Biostatistics Department of Research and Development Kalinga Institute of Medical Sciences KIIT University Bhubaneswar India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratima","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Kalinga Institute of Medical Sciences KIIT University Bhubaneswar India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2545-9032","authenticated-orcid":false,"given":"Prasanta","family":"Padhan","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology Kalinga Institute of Medical Sciences KIIT University Bhubaneswar India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2007.09.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e3181eeb2df"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2011.10.001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/32.2.150"},{"key":"e_1_2_8_6_1","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications","author":"Iber C","year":"2007"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1816152"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.47.2.101"},{"issue":"1","key":"e_1_2_8_9_1","first-page":"1","article-title":"Obstructive sleep apnoea syndrome","volume":"1","author":"L\u00e9vy P","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.189420"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wjorl.2017.05.012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2017.04.001"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.06.011"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2010.02.010"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000100"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-2197.2003.02748.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjsem-2019-000620"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cegh.2019.06.011"},{"issue":"1","key":"e_1_2_8_20_1","first-page":"1","article-title":"Which is the preferred measure of heterogeneity in meta\u2010analysis and why? A Revisit","volume":"1","author":"Pathak M","year":"2017","journal-title":"Biostat Biometrics Open Acc J"},{"issue":"10","key":"e_1_2_8_21_1","article-title":"Risk of Obstructive Sleep Apnea in Rheumatoid Arthritis [abstract]","volume":"70","author":"Katz P","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081335"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.170460"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-009-0975-z"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.2147\/OARRR.S201556"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-013151"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejr.2014.04.002"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbr.2016.06.002"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes210"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.08.1438"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jos.2020.05.010"},{"key":"e_1_2_8_32_1","first-page":"S114","article-title":"Obstructive sleep apnea in RA patients and effect of CPAP on RA activity [Abstract]","volume":"48","author":"Shimizu M","year":"2003","journal-title":"Arthritis Rheum"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.50.6.692"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181c691df"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjebm-2017-110853"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14178","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.14178","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:05:11Z","timestamp":1693209911000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.14178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,19]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/1756-185X.14178"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.14178","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,19]]},"assertion":[{"value":"2021-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}