{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:10:04Z","timestamp":1793157004010,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To review the clinical features of systemic lupus erythematosus (SLE) complicated by central nervous system (CNS) infection due to <jats:italic>Listeria monocytogenes<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A patient with SLE receiving high\u2010dose glucocorticoids combined with cyclophosphamide who developed multiple brain abscesses due to <jats:italic>Listeria<\/jats:italic> infection is described. The case is compared with known cases in a literature review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A review of the literature showed that CNS infections are rare bacterial complications of SLE, but they can be a significant cause of mortality, especially those due to <jats:italic>L.\u00a0monocytogenes<\/jats:italic>. The most significant risk factor for listerial meningitis is a prior history of receiving immunosuppressive therapy. At\u2010risk patients should avoid unpasteurized milk and soft cheeses along with deli\u2010style, ready\u2010to\u2010eat prepared meats, particularly poultry products. The case we report is the fifth SLE patient with multiple brain abscesses due to <jats:italic>L.\u00a0monocytogenes<\/jats:italic>, and the first to be discharged with no sequelae. Timely and accurate identification and treatment of CNS infections and neuropsychiatric lupus are very important for favorable disease prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Repeated blood culture is helpful for early diagnosis, and empirical anti\u2010infective treatment that covers <jats:italic>L.\u00a0monocytogenes<\/jats:italic> is recommended for SLE patients with risk factors when CNS infection occurs. A comprehensive assessment might be helpful to distinguish CNS infections from neuropsychiatric SLE. For severe infection, the dosage of steroids does not need to be reduced immediately but can be gradually adjusted based on the results of a comprehensive evaluation of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14226","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T06:26:25Z","timestamp":1634192785000},"page":"1427-1439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multiple brain abscesses due to <i>Listeria monocytogenes<\/i> infection in a patient with systemic lupus erythematosus: A case report and literature review"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9534-0320","authenticated-orcid":false,"given":"Na","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin Medical University General Hospital Tianjin China"},{"name":"Tianjin Clinical Research 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