{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:33:03Z","timestamp":1773282783304,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18H06346"],"award-info":[{"award-number":["18H06346"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K21429"],"award-info":[{"award-number":["19K21429"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to assess the relationship between pain catastrophizing and achievement of 28\u2010joint Disease Activity Score\u2010defined remission of rheumatoid arthritis (RA), considering the presence or absence of systemic inflammation, and to evaluate associated factors for pain catastrophizing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This cross\u2010sectional study included 421 RA outpatients. The relationship between pain catastrophizing and remission was analyzed by adjusting several confounding factors. Univariable and multivariable analyses were performed to determine the relationship between pain catastrophizing and RA\u2010related factors, comorbidities, and lifestyle habits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of pain catastrophizing was 26%. Pain catastrophizing was negatively associated with remission (odds ratio 0.62, 95% confidence interval 0.38\u20101.00, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.048). A multinomial logistic analysis showed that the presence of pain catastrophizing was an independent factor that was negatively correlated with the achievement of remission in the absence of systemic inflammation (odds ratio 0.51, 95% confidence interval 0.28\u20100.93, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.029). Factors associated with elevated ratings on the Pain Catastrophizing Scale were a history of falls within the past year, a Health Assessment Questionnaire score &gt;0.5, and smoking habit. Further, patients' subjective symptoms, including patient global assessment minus evaluator global assessment values \u226520 and high tender joint count minus swollen joint counts, were associated with elevated pain catastrophizing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pain catastrophizing is a major obstacle to achieving remission in RA patients with normal C\u2010reactive protein levels. Advanced physical disability, smoking habit, and history of falls were associated with pain catastrophizing, in addition to patients' subjective symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14231","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T12:27:21Z","timestamp":1635251241000},"page":"1520-1529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Pain catastrophizing hinders Disease Activity Score 28 \u2013 erythrocyte sedimentation rate remission of rheumatoid arthritis in patients with normal C\u2010reactive protein levels"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4571-1362","authenticated-orcid":false,"given":"Tamami","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Epidemiology for Community Health and Medicine Kyoto Prefectural University of Medicine Kyoto 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