{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T04:49:14Z","timestamp":1776055754515,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T00:00:00Z","timestamp":1637539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>There is an unmet need for a reliable biomarker for the differentiation of axial spondyloarthritis (AxSpA) from its mimickers. Serum levels of interleukin\u201022 (IL\u201022) have previously been found to be significantly elevated in patients with AxSpA compared with healthy individuals or persons with osteoarthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients with established or suspected AxSpA were enrolled. The clinical data, as well as results of laboratory and imaging studies, were acquired from patients\u2019 charts. The final diagnosis of definite or probable SpA, or an alternative diagnosis, was determined, and the serum levels of IL\u201022 were examined by enzyme\u2010linked immunosorbent immunoassay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Interleukin\u201022 levels were significantly higher in patients with definite AxSpA (29 patients) compared with patients with alternative diagnoses (14 patients) and healthy volunteers (16 individuals; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 for both comparisons). The sensitivity and specificity of the serum IL\u201022 for the AxSpA diagnosis were 0.68 (95% CI 0.49\u20100.84) and 0.86 (95% CI 0.68\u20100.95), respectively, for the cut\u2010off value of 5\u00a0pg\/mL. In patients with AxSpA, serum IL\u201022 levels did not correlate with modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Ankylosing Spondylitis Disease Activity Score (ASDAS), or serum C\u2010reactive protein.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum IL\u201022 levels are elevated in patients with the clinical diagnosis of AxSpA and can potentially serve as an independent biomarker for the differentiation of AxSpA from its non\u2010inflammatory mimickers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14246","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T09:37:27Z","timestamp":1637573847000},"page":"56-60","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The association between elevated serum interleukin\u201022 and the clinical diagnosis of axial 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