{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:34:57Z","timestamp":1780569297738,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T00:00:00Z","timestamp":1638403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Despite reports of decreased bone mineral density in patients with systemic sclerosis (SSc) in international cohorts, the prevalence of osteoporosis in Australian SSc patients remains unknown. We report rates of dual\u2010energy X\u2010ray absorptiometry (DXA) scanning in an SSc cohort at a tertiary hospital specialized outpatient clinic and the prevalence and associations of osteoporosis in screened patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We performed retrospective chart review to determine if patients underwent DXA scanning between 2007 and 2018 and extracted lumbar spine and femoral neck T\u2010scores, fracture history, and osteoporosis therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 244 patients, 104 (42.6%) underwent DXA scanning and among patients in whom T\u2010scores were available (n = 91), 30 (33.0%) had osteoporosis and 48 (52.7%) had osteopenia. Screened patients were more likely to have longer disease duration (19.9 vs 15.2 years, P = 0.002), calcinosis (50.5% vs 36.4%, P = 0.028), myositis (12.6% vs 0.7%, P &lt; 0.001), synovitis (42.7% vs 28.6%, P = 0.022), ever used prednisolone (76.7% vs 47.1%, P &lt; 0.001) or fractures (23.0% vs 0.0%, P &lt; 0.001). Patients with osteoporosis more commonly had a history of nasogastric feeding, percutaneous endoscopic gastrostomy feeding or intravenous total parenteral nutrition (6.9% vs 0.0%, P = 0.038) and, unexpectedly, less commonly ever used prednisolone (58.6% vs 85.2%, P = 0.005) compared with patients with osteopenia or normal bone density.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We identified high rates of osteoporosis among screened Australian SSc patients. Further assessment in larger, prospective studies is needed to establish guidelines for formal osteoporosis screening in SSc patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14254","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T06:40:57Z","timestamp":1638513657000},"page":"175-181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Screening rates and prevalence of osteoporosis in a real\u2010world, Australian systemic sclerosis cohort"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4675-1788","authenticated-orcid":false,"given":"Gayathri","family":"Bimal","sequence":"first","affiliation":[{"name":"Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Sahhar","sequence":"additional","affiliation":[{"name":"Monash University  Clayton Victoria Australia"},{"name":"Department of Rheumatology Monash Health  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Savanur","sequence":"additional","affiliation":[{"name":"Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene\u2010Siew","family":"Ngian","sequence":"additional","affiliation":[{"name":"Monash University  Clayton Victoria Australia"},{"name":"Department of Rheumatology Monash Health  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30933-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32834ff2e8"},{"issue":"6","key":"e_1_2_8_4_1","first-page":"S\u201028","article-title":"Bone disease in systemic sclerosis: outcomes and associations","volume":"32","author":"Omair MA","year":"2014","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21761"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2019.01.008"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-016-0119-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066991"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740600704296"},{"issue":"10","key":"e_1_2_8_10_1","article-title":"Prevalence of a diagnosis of osteopenia\/osteoporosis amongst patients with systemic sclerosis and identification of associated clinical factors [abstract]","volume":"72","author":"Wang G","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"e_1_2_8_11_1","article-title":"Risk factors for fractures and osteoporosis among patients with systemic sclerosis in a United States Cohort [abstract]","volume":"72","author":"Famenini S","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1968"},{"key":"e_1_2_8_13_1","unstructured":"Australian Institute of Health and WelfareOsteoporosis Canberra: AIHW; 2020:https:\/\/www.aihw.gov.au\/reports\/chronic\u2010musculoskeletal\u2010conditions\/osteoporosis. 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