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We analyzed SSc patients from Guangxi to improve the clinical understanding of this disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data of 470 SSc patients admitted to our institution from October 1,2012 to January 1,2019 were examined. The characteristics of these patients were analyzed using Kaplan\u2010Meier survival analysis. Cox proportional\u2010hazard regression was used to identify prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average age was 50.44\u00a0\u00b1\u00a012.31\u00a0years, 285 patients (60.6%) were women, 2.1% had pneumoconiosis, 58.2% had pulmonary interstitial disease (ILD), 18.7% had pulmonary hypertension (PH), and 3.6% had renal crisis. These patients had diffuse cutaneous systemic sclerosis (dcSSc, 70.2%) or limited cutaneous systemic sclerosis (29.7%), and PH and renal crisis were more common in the dcSSc group. Patients 50\u00a0years old or more had greater prevalences of ILD, PH, and musculoskeletal damage, greater positivity of laboratory biomarkers, and increased mortality (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Seventy\u2010four patients (15.7%) died. The non\u2010survivors were older, had longer disease duration, had higher prevalences of ILD, restrictive ventilation dysfunction, PH, and renal crisis, and had higher levels of creatine kinase myocardial band (CK\u2010MB), C\u2010reactive protein, and immunoglobin A (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Renal crisis, PH, and high CK\u2010MB were independent risk factors for death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pneumoconiosis was more common in SSc patients than the general population from this region. Our patients had a 10\u2010year cumulative survival rate of 74.9%, higher than reported for patients from the US. Renal crisis, PH, and high CK\u2010MB level were independent risk factors for death.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14261","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T10:51:28Z","timestamp":1639133488000},"page":"182-191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical features and prognostic factors of systemic sclerosis in Guangxi, China: Retrospective, single\u2010center study of long\u2010term survival in 470 patients"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4077-2457","authenticated-orcid":false,"given":"Juan","family":"Chen","sequence":"first","affiliation":[{"name":"The Department of Rheumatology Minzu Hospital of Guangxi Zhuang Autonomous Region  Nanning 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