{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T18:11:22Z","timestamp":1782756682043,"version":"3.54.5"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:00:00Z","timestamp":1640044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2022,3]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Predicting radiographic progression is vital for assessing the prognosis of patients with radiographic axial spondyloarthritis, and C\u2010reactive protein (CRP) may be a valuable biomarker for this purpose. This study aimed to investigate the relationship between changes in the CRP level and spinal radiographic progression in patients with radiographic axial spondyloarthritis who were initially treated with non\u2010biologics.<\/jats:p><\/jats:sec>Methods<\/jats:title>Patients with radiographic axial spondyloarthritis who were followed up for 18\u00a0years at a single center and initially treated with nonsteroidal anti\u2010inflammatory drugs and\/or conventional disease\u2010modifying antirheumatic drugs for 3\u00a0months were included. Patients with a CRP level of <0.8\u00a0mg\/dL or 50% of the baseline CRP at 3\u00a0months were assigned to the controlled CRP group (n\u00a0=\u00a0351), and the remaining patients were assigned to the uncontrolled CRP group (n\u00a0=\u00a0452). A generalized estimating equation was used to analyze the differences in the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) between the 2 groups.<\/jats:p><\/jats:sec>Results<\/jats:title>The increase in the mSASSS was slower in the controlled CRP group than in the uncontrolled CRP group (interaction term \u03b2\u00a0=\u00a0\u2212.499, 95% confidence interval \u22120.699 to \u22120.300).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Controlled CRP achieved in response to initial treatment with non\u2010biologic agents for 3\u00a0months was significantly associated with a slower rate of spinal radiographic change in patients with radiographic axial spondyloarthritis. The CRP level at 3\u00a0months after initial non\u2010biologic treatment is a good predictor of radiographic progression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14268","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T04:39:01Z","timestamp":1640147941000},"page":"311-316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Early control of C\u2010reactive protein levels with non\u2010biologics is associated with slow radiographic progression in radiographic axial spondyloarthritis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4212-2634","authenticated-orcid":false,"given":"Bon San","family":"Koo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Inje University Seoul Paik Hospital Inje University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunghun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology Hanyang University Hospital for Rheumatic Diseases Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Seon","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Information Medicine Big Data Research Center Asan Medical Center Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seo Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Statistics and Data Science Korea National Open University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga Young","family":"Ahn","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Korea University Guro Hospital Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hui","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Hanyang University Hospital for Rheumatic Diseases Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Bin","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Hanyang University Hospital for Rheumatic Diseases Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3542-2276","authenticated-orcid":false,"given":"Tae\u2010Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Hanyang University Hospital for Rheumatic Diseases Seoul South 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