{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T13:39:24Z","timestamp":1782135564142,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005950","name":"Hong Kong University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Using diffusion\u2010weighted imaging (DWI)\u2010derived apparent diffusion coefficient (ADC), we aimed to determine the relationship between intensity of spinal inflammation and mobility in patients with axial spondyloarthritis (SpA) in early and later stages of active disease. The Ankylosing Spondylitis Disease Activity Score (ASDAS) was also used for a more comprehensive evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants with axial SpA and back pain were recruited from 10 rheumatology centers. Clinical, biochemical and radiological parameters were collected. Short tau inversion recovery (STIR) sequence magnetic resonance imaging (MRI) and DWI of the spine and sacroiliac (SI) joints were performed. ADC maps were generated. Participants were examined for Bath Ankylosing Spondylitis Metrology Index (BASMI). Linear regression models were used to determine associations between BASMI and various clinical, radiological, and MRI parameters in participants with active inflammation on spinal ADC maps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One\u2010hundred and twenty\u2010seven participants were included in the analyses. Multivariate linear regression showed that mean ADC spine (\u00df\u00a0=\u00a0.16; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03), ASDAS\u2010C\u2010reactive protein (CRP) (\u00df\u00a0=\u00a0.29, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), and ASDAS\u2010erythrocyte sedimentation rate (ESR) (\u00df\u00a0=\u00a0.25, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01) were associated with BASMI. In participants with duration of back pain \u22643\u00a0years, mean spine ADC (\u00df\u00a0=\u00a0.37; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03), ASDAS\u2010CRP (\u00df\u00a0=\u00a0.44; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01), and ASDAS\u2010ESR (\u00df\u00a0=\u00a0.42; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01) were associated with BASMI after adjustment for confounding factors. In participants with duration of back pain &gt;3\u00a0years, only ASDAS\u2010CRP (\u00df\u00a0=\u00a0.25; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01) and ASDAS\u2010ESR (\u00df\u00a0=\u00a0.20; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.20) were associated with BASMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intensity of inflammation and clinical disease activity were independently associated with impairment of spinal mobility. The associations were stronger in early (\u22643\u00a0years) than later disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14278","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T10:55:40Z","timestamp":1641984940000},"page":"317-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Both ASDAS and ADC are associated with spinal mobility in active axial spondyloarthritis: A comparison between early and later disease"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0175-1346","authenticated-orcid":false,"given":"Ho Yin","family":"Chung","sequence":"first","affiliation":[{"name":"Division of Rheumatology and Clinical Immunology The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0640-0676","authenticated-orcid":false,"given":"Shirley Chiu 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