{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:24Z","timestamp":1787013744747,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T00:00:00Z","timestamp":1641168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Considering the concerns regarding the coronavirus disease\u20102019 (COVID\u201019) vaccine safety among pediatric patients with inflammatory rheumatic diseases (IRD) due to a lack of data, an urgent need for studies evaluating safety profiles of vaccines emerged.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Among participants vaccinated by CoronaVac inactive SARS\u2010CoV\u20102 or BNT162b2 messenger RNA (mRNA) COVID\u201019 (Pfizer\u2010BioNTech) vaccine, healthy children under 18 and patients under 21 with an at least 1\u2010year follow\u2010up period in our department for a childhood\u2010onset rheumatic disease were included into this cross\u2010sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 246 subjects (141 [57.3%] females) (biologic group: 43, non\u2010biologic group: 180, healthy control group: 23) were eligible for the study. The median age was 15.34 (12.02\u201020.92) years. The most common adverse events were fatigue (n\u00a0=\u00a068, 27.6%), headache (n\u00a0=\u00a044, 17.9%), myalgia (n\u00a0=\u00a038, 15.4%), arthralgia (n\u00a0=\u00a038, 15.4%), and fever (n\u00a0=\u00a035, 14.2%). Only 3 subjects (2 patients with familial Mediterranean fever, and one healthy child) were considered to experienced serious adverse events, since they required hospitalization. Local reactions were seen in 20 (8.13%), and 27 patients (12.1%) had disease flares within 1 month after the vaccines. Although it was significantly higher in those who received the BNT162b2 mRNA vaccine (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), there was no significant relationship between adverse event frequency and age, gender, the existing diseases, ongoing treatment regimens and pre\u2010vaccination COVID\u201019 histories.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although immunogenicity studies for efficacy of the vaccines and long\u2010term follow\u2010up studies for adverse events monitoring are required, our study indicates an acceptable safety profile of COVID\u201019 vaccines and encourages children with IRD to be vaccinated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.14279","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T06:00:52Z","timestamp":1641189652000},"page":"353-363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Early experience of COVID\u201019 vaccine\u2010related adverse events among adolescents and young adults with rheumatic diseases: A single\u2010center study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6963-9668","authenticated-orcid":false,"given":"Fatih","family":"Haslak","sequence":"first","affiliation":[{"name":"Department of Pediatric Rheumatology Istanbul University\u2010Cerrahpasa Cerrahpasa Medical School  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0137-0460","authenticated-orcid":false,"given":"Aybuke","family":"Gunalp","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology Istanbul University\u2010Cerrahpasa Cerrahpasa Medical School  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1327-0638","authenticated-orcid":false,"given":"Memnune Nur","family":"Cebi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology Istanbul University\u2010Cerrahpasa Cerrahpasa Medical School  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7834-4909","authenticated-orcid":false,"given":"Mehmet","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology Istanbul University\u2010Cerrahpasa Cerrahpasa Medical School  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2400-6955","authenticated-orcid":false,"given":"Amra","family":"Adrovic","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology Istanbul University\u2010Cerrahpasa Cerrahpasa Medical School  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5365-3457","authenticated-orcid":false,"given":"Sezgin","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology Istanbul University\u2010Cerrahpasa Cerrahpasa Medical School  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8459-2872","authenticated-orcid":false,"given":"Kenan","family":"Barut","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology Istanbul University\u2010Cerrahpasa Cerrahpasa Medical School  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1125-7720","authenticated-orcid":false,"given":"Ozgur","family":"Kasapcopur","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology Istanbul University\u2010Cerrahpasa Cerrahpasa Medical School  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01429-X"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2110345"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2005073"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-021-05780-x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.5152\/TurkArchPediatr.2020.20245"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.200755"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa897"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-020-04645-x"},{"issue":"6","key":"e_1_2_8_10_1","first-page":"1271","article-title":"The frequency and clinical course of COVID\u201019 infection in children with juvenile idiopathic arthritis","volume":"38","author":"Yildiz M","year":"2020","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217424"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05189-y"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.210288"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-221244"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41928"},{"issue":"7","key":"e_1_2_8_16_1","first-page":"64","article-title":"Monitoring vaccine adverse event reporting system (VAERS) reports related to COVID\u201019 vaccination efforts in Rhode Island","volume":"104","author":"Karayeva E","year":"2021","journal-title":"R I Med J (2013)"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-220272"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41937"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112922"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2021-001814"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-021-05017-9"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-021-04972-7"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-eular.5097"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41977"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01469-5"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-221496"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-220647"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.05.015"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00434-6"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-219498"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2021.1955101"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2021.10.025"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/emp2.12565"},{"key":"e_1_2_8_34_1","first-page":"100042","article-title":"Myocarditis following mRNA vaccination against SARS\u2010CoV\u20102, a case series","volume":"8","author":"King WW","year":"2021","journal-title":"Am Heart J plus"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14279","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.14279","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T10:30:37Z","timestamp":1693132237000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.14279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,3]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/1756-185X.14279"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.14279","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,3]]},"assertion":[{"value":"2021-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}