{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:46:02Z","timestamp":1785577562428,"version":"3.56.0"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study is to evaluate the association between <jats:italic>Klebsiella pneumoniae<\/jats:italic> infection and ankylosing spondylitis (AS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Five electronic databases, PubMed, Embase, Medline, Web of Science, and Scopes, were searched until September 29, 2021. Cohort and case\u2010control studies that assessed the association between <jats:italic>K. pneumoniae<\/jats:italic> infection and AS were included. Pooled odds ratio (OR) was selected to show the effect size. Subgroup analysis (active or inactive AS) and 2 forms of sensitivity analysis were conducted. All statistical analyses were conducted by using STATA 12.0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 25 case\u2010control studies finally included, including 8 studies concerning presence of <jats:italic>K. pneumoniae<\/jats:italic> in feces, and 17 studies concerning serum antibody (immunoglobulin [Ig]G, IgM, IgA) against <jats:italic>K. pneumoniae<\/jats:italic>. The results suggested that when compared with healthy people, presence of <jats:italic>K. pneumoniae<\/jats:italic> in feces was associated with AS (OR: 5.65; 95% CI: 1.68\u201019.00). Similarly, when compared with healthy people, higher positive rates of IgA (OR: 6.28; 95% CI: 3.32\u201011.91) and IgG (OR: 5.22; 95% CI: 1.36\u201019.99) were observed. Subgroup analyses suggested that association between <jats:italic>K. pneumoniae<\/jats:italic> and AS appears stronger in active AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>When compared with healthy people, a significantly higher positive rate of <jats:italic>K. pneumoniae<\/jats:italic> in feces, serum IgA and IgG were observed in patients with AS, suggesting that <jats:italic>K. pneumoniae<\/jats:italic> probably plays a crucial role in the occurrence of AS. The findings in this study need further prospective investigations for confirmation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14283","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T11:13:53Z","timestamp":1641986033000},"page":"422-432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association between <i>Klebsiella pneumoniae<\/i> and ankylosing spondylitis: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"25","author":[{"given":"Fayu","family":"Long","sequence":"first","affiliation":[{"name":"Department of Orthopedics Chengdu Second People's Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Chengdu Second People's Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Chengdu Second People's Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiquan","family":"Xiong","sequence":"additional","affiliation":[{"name":"Chinese Evidence\u2010based Medicine Center West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7896-393X","authenticated-orcid":false,"given":"Yong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Chengdu Second People's Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60635-7"},{"issue":"3","key":"e_1_2_8_3_1","first-page":"64","article-title":"Ankylosing spondylitis: a summary and review","volume":"2","author":"Walker BF","year":"1993","journal-title":"COMSIG Rev"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2009.02.006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0855-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12605"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-015-3342-x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2011.0183"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032414-112110"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2018.02.020"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00006845"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.37.2.146"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.70.2.85"},{"issue":"1","key":"e_1_2_8_14_1","first-page":"92","article-title":"Ankylosing spondylitis, HLA\u2010B27 and Klebsiella. 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