{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:24:29Z","timestamp":1787793869103,"version":"build-2784847793"},"reference-count":8,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T00:00:00Z","timestamp":1642032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a case of eosinophilic fasciitis triggered by strenuous physical activity, which did not relapse during the follow\u2010up period. We ascertained that interleukin\u201033 (IL\u201033) was released from the vascular endothelial cells after intense exercise, inducing type 2 innate lymphocytes (ILC2) and causing fasciitis. A healthy woman experienced itching on both limbs a few hours after a game of drumming. Her hand, knee joints, and legs gradually swelled up with groove signs along the superficial veins. White blood cell and eosinophil counts were significantly elevated. Magnetic resonance imaging revealed a high signal at the fascia on both lower limbs. Histopathological findings of the left lower limb tissue specimen showed edematous fascia with eosinophils. No relapse of eosinophilic fasciitis was observed after finishing treatment with prednisolone. Immunological staining for IL\u20104, IL\u20105, IL\u201033, tumor necrosis factor\u2010\u03b1, and interferon\u2010\u03b3 was performed on the fascial tissue. Both IL\u20104 and IL\u20105 were stained on the lymphocytes at the muscle and fascia levels; however, CD3 and CD4 were unstained in these cells, suggesting that those cells were ILC2. Tumor necrosis factor\u2010\u03b1 and interferon\u2010\u03b3 were unstained. Vascular endothelial cells in the fascia strongly expressed IL\u201033. Eosinophilic fasciitis may be associated with type 2 immunity triggered by IL\u201033 in the current case.<\/jats:p>","DOI":"10.1111\/1756-185x.14284","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T09:00:38Z","timestamp":1642064438000},"page":"364-366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Eosinophilic fasciitis induced by a game of drumming probably via type 2 innate immunity"],"prefix":"10.1111","volume":"25","author":[{"given":"Seimi","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Dermatology Mie University Graduate School of Medicine  Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1560-6067","authenticated-orcid":false,"given":"Makoto","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mie University Graduate School of Medicine  Tsu 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