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The objective of this study was to conduct a systematic review of disease burden for RA in Argentina, Brazil, Colombia, Mexico, and Venezuela. PubMed\/Medline, Embase, and Web of Science were searched for publications in English, Spanish, or Portuguese from 2008 through June 2018. A total of 1700 records were retrieved and 36 articles were included. The estimated prevalence of RA for these countries ranged from 0.15% (Colombia) to 2.8% (Mexico). The Global Burden of Disease initiative 2019 estimated that RA accounted for 0.13% of world disability\u2010adjusted life\u2010years. For Latin America, these figures were higher: Argentina 0.16%, Brazil 0.16%, Colombia 0.21%, Mexico 0.30%, and Venezuela 0.24%. RA has a negative impact on physical, mental, and emotional well\u2010being as shown by substantially lower scores on measures of quality of life (SF\u201036) compared with the general population. The annual direct cost in Mexico was estimated at US$3599 per person. For patients with severe RA in Brazil these costs were approximately US$10\u00a0000. Data from other studied countries were similar. Though evidence of the full cost and impact of RA in Latin American countries is scarce and additional studies are needed, the burden of RA in these regions is significant and comparable to other parts the world.<\/jats:p>","DOI":"10.1111\/1756-185x.14295","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T07:05:59Z","timestamp":1643699159000},"page":"405-421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The burden of illness of rheumatoid arthritis in Latin America\u2014A systematic literature review"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3688-523X","authenticated-orcid":false,"given":"Emmanuel","family":"Papadimitropoulos","sequence":"first","affiliation":[{"name":"Eli Lilly and Company  Toronto Ontario Canada"},{"name":"Faculty of Pharmacy University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Brnabic","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Vorstenbosch","sequence":"additional","affiliation":[{"name":"Parc Sanitari Sant Joan de Deu  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice","family":"Leonardi","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Moyano","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Gomez","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes305"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2013.08.2230"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.5772\/26724"},{"key":"e_1_2_6_6_1","first-page":"721","article-title":"One year in review 2017: novelties in the treatment of rheumatoid arthritis","volume":"35","author":"Ferro F","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei500"},{"key":"e_1_2_6_8_1","first-page":"219","article-title":"Cost of rheumatoid arthritis in a selected population from Argentina in the prebiologic therapy era","volume":"4","author":"Catay E","year":"2012","journal-title":"Clinicoecon Outcomes Res"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"A891","DOI":"10.1016\/j.jval.2017.08.2679","article-title":"Treatment patterns and satisfaction for rheumatoid arthritis patients In Latin America undergoing advanced therapy","volume":"20","author":"Papadimitropoulos M","year":"2017","journal-title":"Value Health"},{"key":"e_1_2_6_10_1","volume-title":"GBD Compare","author":"Institute for Health Metrics and Evaluation (IHME)","year":"2015"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.151262"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e3181f3bfdd"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3192-2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2255-5021(13)70006-3"},{"key":"e_1_2_6_15_1","first-page":"11","article-title":"Prevalencia de artritis reumatoide en Colombia: una aproximaci\u00f3n basada en la carga de la enfermedad durante el a\u00f1o 2005","volume":"23","author":"D\u00edaz\u2010Rojas JA","year":"2016","journal-title":"Rev Colomb Reumatol"},{"key":"e_1_2_6_16_1","first-page":"148","article-title":"The epidemiology of rheumatoid arthritis in a cohort of Colombian patients","volume":"22","author":"Machado\u2010Alba JE","year":"2015","journal-title":"Rev Colomb Reumatol"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2013.08.2235"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000000223"},{"key":"e_1_2_6_19_1","first-page":"3","article-title":"Epidemiology of the rheumatic diseases in Mexico. 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