{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T20:48:26Z","timestamp":1778791706253,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Palindromic rheumatism (PR) is characterized by self\u2010resolving and short duration attacks of arthritis\/periarthritis. The present study was performed to report the results of PR treatment with methotrexate (MTX).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the charts of 152 patients with diagnosis of PR. Inclusion criteria were diagnosis of PR according to the criteria of Weismann, age \u226516, active disease and treatment with MTX for at least 6\u00a0months. Disease outcome was assessed by reaching remission and prevention of disease evolution to chronic arthritis. Remission was defined as stopping the attacks for 12\u00a0weeks and prednisolone dose \u22645\u00a0mg\/d. MTX treatment failure was defined as failure to achieve remission, the need to add other disease\u2010modifying antirheumatic drugs and disease progression to chronic arthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010nine patients were included in the study. Median duration of follow\u2010up was 43\u00a0months. Attacks were controlled in 89.8% of patients. In 80% of the patients remission occurred during 12\u00a0months after starting treatment with MTX. Treatment failed in 20.3% of patients. Wrist joint involvement and positive rheumatoid factor (RF) were significantly more common in the MTX treatment\u2010failed group. In RF positive patients evolution to rheumatoid arthritis was more common than in RF negative patients. No significant differences were observed in remission rate and evolution to rheumatoid arthritis in anticitrullinated C peptide positive and negative patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study, demonstrated the efficacy of MTX in controlling PR in seropositive and seronegative patients over a median of 43\u00a0months of treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14302","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T10:38:33Z","timestamp":1644316713000},"page":"489-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Long\u2010term outcome of patients with palindromic rheumatism treated with methotrexate"],"prefix":"10.1111","volume":"25","author":[{"given":"Arezoo","family":"Ghassembaglou","sequence":"first","affiliation":[{"name":"Connective Tissue Diseases Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Esalatmanesh","sequence":"additional","affiliation":[{"name":"Autoimmune Diseases Research Center Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leyla","family":"Gadakchi","sequence":"additional","affiliation":[{"name":"Connective Tissue Diseases Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farnaz","family":"Nourmohammadi","sequence":"additional","affiliation":[{"name":"Autoimmune Diseases Research Center Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9482-6967","authenticated-orcid":false,"given":"Alireza","family":"Khabbazi","sequence":"additional","affiliation":[{"name":"Connective Tissue Diseases Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2017.09.014"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2021.1899811"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.657983"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.190061"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.14868"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2217\/ijr.13.51"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.5152\/eurjrheum.2021.20062"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(92)90177-D"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2019.01.002"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328329c79d"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-019-0308-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214175"},{"issue":"8","key":"e_1_2_9_14_1","first-page":"1650","article-title":"Is there subclinical synovitis in patients with palindromic rheumatism in the intercritical period? a clinical and ultrasonographic study according to anticitrullinated protein antibody status","volume":"41","author":"Cabrera\u2010Villalba S","year":"2014","journal-title":"Rheumatol"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2021.105235"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22755"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208138"},{"key":"e_1_2_9_18_1","first-page":"72","article-title":"In ACPA positive at\u2010 risk individuals, which MRI and US findings best predict development of clinical synovitis?","volume":"77","author":"Hunt L","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.05.002"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/lmaa095"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X20978139"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.4997\/JRCPE.2021.306"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322006000600016"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.07.012"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-014-2569-3"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090025"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1544-9"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14302","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.14302","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T17:36:40Z","timestamp":1692985000000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.14302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,8]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/1756-185X.14302"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.14302","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,8]]},"assertion":[{"value":"2021-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}