{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:31:49Z","timestamp":1747182709551,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,20]],"date-time":"2022-02-20T00:00:00Z","timestamp":1645315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To provide in\u2010depth understanding of real\u2010world tumor necrosis factor inhibitor (TNFi) treatment patterns in patients with ankylosing spondylitis (AS) and treatment satisfaction, productivity loss, and associated factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a multicenter observational hybrid retrospective chart review and cross\u2010sectional survey study. Disease activity and physical functioning were measured using the Bath AS Disease Activity Index and Bath AS Functional Index, respectively. Treatment satisfaction was determined with the Treatment Satisfaction Questionnaire for Medication (TSQM). Productivity loss was evaluated using the Korean version of the World Health Organization\u2013Health and Work Performance Questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 497 patients were enrolled (mean age 40.3\u00a0years, 85.3% male, mean AS duration 10\u00a0years). The mean duration of TNFi treatment was 6.2\u00a0years. Among the four TNFi considered, adalimumab (39.6%) and etanercept (23.5%) were most commonly used at study enrollment. The TSQM convenience domain score was lower than scores in the effectiveness, adverse effects, and global satisfaction domains. Subcutaneous syringe\u2010type injection and intravenous injection were associated with lower patient convenience satisfaction than subcutaneous pen\u2010type injection. Increased costs of lost productivity time were associated with female sex, unemployed status, and higher disease activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The most frequently prescribed TNFi was adalimumab, followed by etanercept. Etanercept was used for the longest duration. More convenient treatment options may enhance overall treatment satisfaction. Considerable loss in productivity due to AS was observed in this study. To reflect patients\u2019 perspectives, further attention should be paid to factors associated with treatment satisfaction and productivity loss when selecting treatment options.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14304","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T05:28:21Z","timestamp":1645421301000},"page":"523-531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Treatment pattern, satisfaction, and productivity loss of patients with ankylosing spondylitis treated with tumor necrosis factor inhibitors in Korea: A multicenter cross\u2010sectional observational study"],"prefix":"10.1111","volume":"25","author":[{"given":"Sang\u2010Hoon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Hospital at Gangdong Kyung Hee University  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8029-7355","authenticated-orcid":false,"given":"Yong\u2010Gil","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5205-3978","authenticated-orcid":false,"given":"Seung\u2010Geun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Pusan National University Hospital  Pusan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Medical Pfizer Biopharmaceuticals Group Pfizer Pharmaceuticals Korea Limited  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Joo","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Medical Pfizer Biopharmaceuticals Group Pfizer Pharmaceuticals Korea Limited  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ja\u2010Young","family":"Jeon","sequence":"additional","affiliation":[{"name":"Division of Medical Pfizer Biopharmaceuticals Group Pfizer Pharmaceuticals Korea Limited  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo\u2010Young","family":"Jo","sequence":"additional","affiliation":[{"name":"Division of Medical Pfizer Biopharmaceuticals Group Pfizer Pharmaceuticals Korea Limited  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun\u2010Jeong","family":"Yoo","sequence":"additional","affiliation":[{"name":"Division of Medical Pfizer Biopharmaceuticals Group Pfizer Pharmaceuticals Korea Limited  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juneyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biostatistics College of Medicine Korea University  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3542-2276","authenticated-orcid":false,"given":"Tae\u2010Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Hanyang University Hospital for Rheumatic Diseases  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,20]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_9_2_1","DOI":"10.1016\/S0140-6736(07)60635-7"},{"doi-asserted-by":"publisher","key":"e_1_2_9_3_1","DOI":"10.1093\/rheumatology\/ket387"},{"doi-asserted-by":"publisher","key":"e_1_2_9_4_1","DOI":"10.1007\/s00296-002-0237-4"},{"doi-asserted-by":"publisher","key":"e_1_2_9_5_1","DOI":"10.1038\/s41598-018-25933-4"},{"doi-asserted-by":"publisher","key":"e_1_2_9_6_1","DOI":"10.1002\/acr.22253"},{"doi-asserted-by":"publisher","key":"e_1_2_9_7_1","DOI":"10.1136\/annrheumdis-2016-210770"},{"issue":"4","key":"e_1_2_9_8_1","first-page":"246","article-title":"Analysis of drug utilization for patients with ankylosing spondylitis","volume":"25","author":"Kang HB","year":"2015","journal-title":"Korean J Clin Pharm"},{"doi-asserted-by":"publisher","key":"e_1_2_9_9_1","DOI":"10.1517\/14712590903530633"},{"doi-asserted-by":"publisher","key":"e_1_2_9_10_1","DOI":"10.1002\/art.1780270401"},{"doi-asserted-by":"publisher","key":"e_1_2_9_11_1","DOI":"10.1016\/j.jval.2010.11.006"},{"unstructured":"Korean Statistical Information Service (KOSIS).Annual wage a labor time; 29 2020. 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