{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:55:01Z","timestamp":1792446901136,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine the effect of exercise training programs with aerobic components on C\u2010reactive protein, erythrocyte sedimentation rate and self\u2010assessed disease activity in people with ankylosing spondylitis compared to non\u2010aerobic rehabilitation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review was undertaken of PubMED, Cochrane Library, Embase and Web of Science databases. Articles evaluating the effect of exercise training programs with aerobic components on C\u2010reactive protein, erythrocyte sedimentation rate or Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in adults (&gt;17\u00a0years) with ankylosing spondylitis were included. Control groups were defined as non\u2010aerobic rehabilitation, including usual care or physiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen articles met inclusion criteria for qualitative and meta\u2010analysis, involving 366 participants undertaking exercise and 361 controls. Exercise programs included modalities such as running, aerobic walking and swimming, and were between 3\u00a0weeks and 3\u00a0months in duration. Exercise programs significantly reduced C\u2010reactive protein (weighted mean difference [WMD]: \u22121.09; 95% CI: \u22122.08 to \u22120.10; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03; n\u00a0=\u00a05) and BASDAI (WMD: \u22120.78; 95% CI: \u22120.98 to \u22120.58; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001; n\u00a0=\u00a013) compared to non\u2010aerobic rehabilitation. BASDAI subgroup analysis revealed greater improvements compared to usual care than structured physiotherapy. Exercise programs did not reduce erythrocyte sedimentation rate (WMD: 0.16; 95% CI: \u22122.15 to 2.47; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.89; n\u00a0=\u00a04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Exercise training programs with aerobic components reduced C\u2010reactive protein and improved self\u2010assessed disease activity in people with ankylosing spondylitis. Further research is required to investigate the effects of differing aerobic exercise modes, intensities and durations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14315","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T07:42:47Z","timestamp":1646984567000},"page":"635-649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The effect of exercise training programs with aerobic components on C\u2010reactive protein, erythrocyte sedimentation rate and self\u2010assessed disease activity in people with ankylosing spondylitis: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0551-6191","authenticated-orcid":false,"given":"Conrad","family":"Harpham","sequence":"first","affiliation":[{"name":"College of Life and Environmental Science University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quillon K.","family":"Harpham","sequence":"additional","affiliation":[{"name":"Independent  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R.","family":"Barker","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Science University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1406182"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket387"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60635-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30581"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207688"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-019-0057-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24838"},{"key":"e_1_2_8_9_1","first-page":"23","article-title":"A new approach to defining disease status in as\u2010the Bath Ankylosing\u2010Spondylitis Disease\u2010Activity Index (BASDAI)","volume":"32","author":"Garrett SL","year":"1993","journal-title":"Brit J Rheumatol"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.SMJ.0000066946.56322.3C"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00098"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01028.2006"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210770"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13352"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2017.07.015"},{"key":"e_1_2_8_16_1","first-page":"CD011321","article-title":"Exercise programmes for ankylosing spondylitis","volume":"10","author":"Regnaux JP","year":"2019","journal-title":"Cochrane Db Syst Rev"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13385"},{"key":"e_1_2_8_18_1","first-page":"372","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"29","author":"Page MJ","year":"2021","journal-title":"BMJ"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22342"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.151244"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00131-0"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20070147"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604"},{"issue":"4","key":"e_1_2_8_24_1","first-page":"449","article-title":"Are swimming or aerobic exercise better than conventional exercise in ankylosing spondylitis patients? 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