{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:12:35Z","timestamp":1775470355474,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Anti\u2010mitochondrial antibodies (AMAs) are associated with distinct clinical phenotypes including cardiac and hepatic manifestations in idiopathic inflammatory myopathies (IIMs). This article studies the prevalence, clinical characteristics and outcomes of AMA in Indian patients with IIM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients (97: 81 adult, 16 juvenile) clinically diagnosed with polymyositis or antibody\u2010negative IIM were retrieved from the MyoCite bio\u2010archive. They were tested for myositis\u2010specific autoantibodies \/ myositis autoantibodies (MSAs\/MAAs) using line immunoassay and antinuclear antibodies and AMAs using immunofluorescence assay (IFA). Patients were also screened for cardiac biomarkers (cardiac troponin I [c\u2010TnI] and N terminal\u2010pro brain natriuretic peptide [NT\u2010pro\u2010BNP] using immunometric immunoassay technique and enhanced chemiluminescence assay testing respectively) and hepatic manifestations using AMA testing. Results were formulated after carrying out analytical tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the cohort, 5 adults (6.2%) (M:F 0:1) with a median age and disease duration of 37 years and 2 months respectively, tested AMA+ while the children tested negative. Dermatomyositis was the commonest phenotype, with amyopathic forms being common, often with MSA positivity. Cancer\u2010associated myositis and polymyositis were also seen. AMA positivity is associated with Gottron's sign and calcinosis. Comparable levels of C\u2010TnI and NT\u2010pro\u2010BNP and AMA testing in patients help to rule out subclinical cardiac and hepatic involvement respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anti\u2010mitochondrial antibodies are rare (6.2%) in different subtypes of IIM in the Indian population, and often coexist with MSAs. Their negative association with cardiac and hepatic involvement and probable association with Gottron's sign and calcinosis merit further investigation and long\u2010term follow\u2010up to understand the entire spectrum of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14320","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T09:09:00Z","timestamp":1649236140000},"page":"659-668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Anti\u2010mitochondrial antibodies in Indian patients with idiopathic inflammatory myopathies"],"prefix":"10.1111","volume":"25","author":[{"given":"Prithvi Sanjeevkumar","family":"Gaur","sequence":"first","affiliation":[{"name":"Smt. Kashibai Navale Medical College and General Hospital  Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2014-3925","authenticated-orcid":false,"given":"Naveen","family":"R","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anamika Kumari","family":"Anuja","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mantabya Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Nephrology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohit 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